Interleukins in cancer: from biology to therapy
Interleukins and associated cytokines serve as the means of communication for innate and
adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a …
adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a …
Next generation of immune checkpoint inhibitors and beyond
JA Marin-Acevedo, EMO Kimbrough, Y Lou - Journal of hematology & …, 2021 - Springer
The immune system is the core defense against cancer development and progression.
Failure of the immune system to recognize and eliminate malignant cells plays an important …
Failure of the immune system to recognize and eliminate malignant cells plays an important …
Beyond conventional immune-checkpoint inhibition—novel immunotherapies for renal cell carcinoma
The management of advanced-stage renal cell carcinoma (RCC) has been transformed by
the development of immune-checkpoint inhibitors (ICIs). Nonetheless, most patients do not …
the development of immune-checkpoint inhibitors (ICIs). Nonetheless, most patients do not …
Neutralizing IL-8 potentiates immune checkpoint blockade efficacy for glioma
H Liu, Q Zhao, L Tan, X Wu, R Huang, Y Zuo, L Chen… - Cancer cell, 2023 - cell.com
Malignant gliomas are largely refractory to immune checkpoint blockade (ICB) therapy. To
explore the underlying immune regulators, we examine the microenvironment in glioma and …
explore the underlying immune regulators, we examine the microenvironment in glioma and …
Single-cell transcriptome profiling of the stepwise progression of head and neck cancer
Head and neck squamous cell carcinoma (HNSCC) undergoes stepwise progression from
normal tissues to precancerous leukoplakia, primary HNSCC, and metastasized tumors. To …
normal tissues to precancerous leukoplakia, primary HNSCC, and metastasized tumors. To …
CXCL8 in tumor biology and its implications for clinical translation
X **ong, X Liao, S Qiu, H Xu, S Zhang… - Frontiers in molecular …, 2022 - frontiersin.org
The chemokine CXCL8 has been found to play an important role in tumor progression in
recent years. CXCL8 activates multiple intracellular signaling pathways by binding to its …
recent years. CXCL8 activates multiple intracellular signaling pathways by binding to its …
Tumor-associated neutrophils in hepatocellular carcinoma pathogenesis, prognosis, and therapy
Simple Summary Hepatocellular carcinoma is the most prevalent primary liver cancer,
accounting for> 80% of primary liver cancers worldwide. Inflammation has come to light as a …
accounting for> 80% of primary liver cancers worldwide. Inflammation has come to light as a …
Randomized phase II study of nivolumab with or without ipilimumab combined with stereotactic body radiotherapy for refractory metastatic pancreatic cancer …
IM Chen, JS Johansen, S Theile, JX Hjaltelin… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE To evaluate the clinical benefit of nivolumab with or without ipilimumab in
combination with stereotactic body radiotherapy (SBRT) in patients with refractory metastatic …
combination with stereotactic body radiotherapy (SBRT) in patients with refractory metastatic …
Dysregulation of immunity by cigarette smoking promotes inflammation and cancer: a review
Smoking is a serious global health issue. Cigarette smoking contains over 7000 different
chemicals. The main harmful components include nicotine, acrolein, aromatic hydrocarbons …
chemicals. The main harmful components include nicotine, acrolein, aromatic hydrocarbons …
Peripheral blood-based biomarkers for immune checkpoint inhibitors
As cancer immunotherapy using immune checkpoint inhibitors (ICIs) is rapidly evolving in
clinical practice, it is necessary to identify biomarkers that will allow the selection of cancer …
clinical practice, it is necessary to identify biomarkers that will allow the selection of cancer …