T cells are essential immune cells responsible for identifying and eliminating pathogens.
Through interactions between their T-cell antigen receptors (TCRs) and antigens presented …

The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …

T cells are defined by a heterodimeric surface receptor, the T cell receptor (TCR), that
mediates recognition of pathogen-associated epitopes through interactions with peptide and …

Motivation While growing numbers of T cell receptor (TCR) repertoires are being mapped by
high-throughput sequencing, existing methods do not allow for computationally connecting a …

Despite the growing number of immune repertoire sequencing studies, the field still lacks
software for analysis and comprehension of this high-dimensional data. Here we report …

Background The T-cell receptor (TCR), located on the surface of T cells, is responsible for
the recognition of the antigen-major histocompatibility complex, leading to the initiation of an …

T cell discrimination of self and non-self is predicated on αβ T cell receptor (TCR) co-
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …

The COVID-19 pandemic caused by SARS-CoV-2 is a continuous challenge worldwide, and
there is an urgent need to map the landscape of immunogenic and immunodominant …

Antibody-antigen binding relies on the specific interaction of amino acids at the paratope-
epitope interface. The predictability of antibody-antigen binding is a prerequisite for de novo …

Obesity and its associated metabolic syndromes represent a growing global challenge, yet
mechanistic understanding of this pathology and current therapeutics are unsatisfactory. We …