Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …

Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …

Diabetic foot ulcers and other chronic wounds with impaired healing can be treated with
bioengineered skin or with growth factors. However, most patients do not benefit from these …

Wound healing is one of the most complex processes in the human body. It involves the
spatial and temporal synchronization of a variety of cell types with distinct roles in the …

Hypertrophic scars and keloids are fibroproliferative disorders that may arise after any deep
cutaneous injury caused by trauma, burns, surgery, etc. Hypertrophic scars and keloids are …

Fibroblasts are cells present throughout the human body that are primarily responsible for
the production and maintenance of the extracellular matrix (ECM) within the tissues. They …

Skin wound dressings are commonly used to stimulate and enhance skin tissue repair. Even
if wounds seem easy to repair for clinicians and to replicate in an in vitro set-up for scientists …

The importance of proper skin wound healing becomes evident when our body's repair
mechanisms fail, leading to either non-healing (chronic) wounds or excessive repair …

Tissue injury disrupts the mechanical homeostasis that underlies normal tissue architecture
and function. The failure to resolve injury and restore homeostasis gives rise to progressive …

Hypertrophic scars and keloids can be aesthetically displeasing and lead to severe
psychosocial impairment. Many invasive and non-invasive options are available for the …