The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission
Mounting evidence suggests that acute and chronic stress, especially the stress-induced
release of glucocorticoids, induces changes in glutamate neurotransmission in the prefrontal …
release of glucocorticoids, induces changes in glutamate neurotransmission in the prefrontal …
Major depressive disorder
RH Belmaker, G Agam - New England Journal of Medicine, 2008 - Mass Medical Soc
This review of major depressive disorder is a comprehensive account of the genetic,
biochemical, and neurophysiological changes that have been implicated in the disorder. No …
biochemical, and neurophysiological changes that have been implicated in the disorder. No …
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression
Context Existing therapies for major depression have a lag of onset of action of several
weeks, resulting in considerable morbidity. Exploring pharmacological strategies that have …
weeks, resulting in considerable morbidity. Exploring pharmacological strategies that have …
Management of treatment-resistant depression: challenges and strategies
Abstract Treatment-resistant depression (TRD) is a subset of Major Depressive Disorder
which does not respond to traditional and first-line therapeutic options. There are several …
which does not respond to traditional and first-line therapeutic options. There are several …
Ketamine and the neurobiology of depression: Toward next-generation rapid-acting antidepressant treatments
Ketamine has emerged as a transformative and mechanistically novel pharmacotherapy for
depression. Its rapid onset of action, efficacy for treatment-resistant symptoms, and …
depression. Its rapid onset of action, efficacy for treatment-resistant symptoms, and …
New approaches to antidepressant drug discovery: beyond monoamines
All available antidepressant medications are based on serendipitous discoveries of the
clinical efficacy of two classes of antidepressants more than 50 years ago. These tricyclic …
clinical efficacy of two classes of antidepressants more than 50 years ago. These tricyclic …
Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders
Half a century after the first formulation of the monoamine hypothesis, compelling evidence
implies that long-term changes in an array of brain areas and circuits mediating complex …
implies that long-term changes in an array of brain areas and circuits mediating complex …
Prefrontal cortex circuits in depression and anxiety: contribution of discrete neuronal populations and target regions
Our understanding of depression and its treatment has advanced with the advent of
ketamine as a rapid-acting antidepressant and the development and refinement of tools …
ketamine as a rapid-acting antidepressant and the development and refinement of tools …
[HTML][HTML] Cortical GABAergic dysfunction in stress and depression: new insights for therapeutic interventions
Major depressive disorder (MDD) is a debilitating illness characterized by neuroanatomical
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …
The GABAergic deficit hypothesis of major depressive disorder
B Luscher, Q Shen, N Sahir - Molecular psychiatry, 2011 - nature.com
Increasing evidence points to an association between major depressive disorders (MDDs)
and diverse types of GABAergic deficits. In this review, we summarize clinical and preclinical …
and diverse types of GABAergic deficits. In this review, we summarize clinical and preclinical …