The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Cardiac ATP production primarily depends on oxidative phosphorylation in mitochondria
and is dynamically regulated by Ca 2+ levels in the mitochondrial matrix as well as by …

Skeletal muscle hypertrophy can be induced by hormones and growth factors acting directly
as positive regulators of muscle growth or indirectly by neutralizing negative regulators, and …

Mitochondria are the primary source of energy production and are implicated in a wide
range of biological processes in most eukaryotic cells. Skeletal muscle heavily relies on …

Classically, mitochondria have largely been believed to influence the development of illness
by modulating cell metabolism and determining the rate of production of high-energy …

Mitochondrial damage is implicated as a major contributing factor for a number of
noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and …

Summary Uncoupling protein 1 (UCP1)-mediated adaptive thermogenesis protects
mammals against hypothermia and metabolic dysregulation. Whether and how …

Sarcopenia burdens the older population through loss of muscle energy and mass, yet
treatments to functionally rescue both parameters are lacking. The glucocorticoid …

Recently, the role of mitochondrial activity in high-energy demand organs and in the
orchestration of whole-body metabolism has received renewed attention. In mitochondria …

Mitochondrial Ca2+ overload can mediate mitochondria-dependent cell death, a major
contributor to several human diseases. Indeed, Duchenne muscular dystrophy (MD) is …