A class of cis-regulatory elements, called enhancers, play a central role in orchestrating
spatiotemporally precise gene-expression programs during development. Consequently …

Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …

The arrangement (syntax) of transcription factor (TF) binding motifs is an important part of the
cis-regulatory code, yet remains elusive. We introduce a deep learning model, BPNet, that …

Short tandem repeats (STRs) are enriched in eukaryotic cis-regulatory elements and alter
gene expression, yet how they regulate transcription remains unknown. We found that STRs …

Differential gene expression gives rise to the many cell types of complex organisms.
Enhancers regulate transcription by binding transcription factors (TFs), which in turn recruit …

Prime editors consisting of Cas9-nickase and reverse transcriptase enable targeted precise
editing of small DNA pieces, including all 12 kinds of base substitutions, insertions and …

Enhancers are important genomic regulatory elements directing cell type-specific
transcription. They assume a key role during development and disease, and their …

Enhancer sequences control gene expression and comprise binding sites (motifs) for
different transcription factors (TFs). Despite extensive genetic and computational studies, the …

Determining whether and how a gene is transcribed are two of the central processes of life.
The conceptual basis for understanding such gene regulation arose from pioneering …

Prokaryotic regulatory proteins respond to diverse signals and represent a rich resource for
building synthetic sensors and circuits. The TetR family contains> 105 members that use a …