Intravital microscopy (IVM) study approach offers several advantages over in vitro, ex vivo,
and 3D models. IVM provides real-time imaging of cellular events, which provides us a …

Nonmuscle myosin II is an actin-based motor that executes numerous mechanical tasks in
cells including spatiotemporal organization of the actin cytoskeleton, adhesion, migration …

The mechanical properties of the actin cortex regulate shape changes during cell division,
cell migration, and tissue morphogenesis. We show that modulation of myosin II (MII) …

Tissues are heterogeneous with respect to cellular and non-cellular components and in the
dynamic interactions between these elements. To study the behaviour and fate of individual …

Cellular secretion depends on exocytosis of secretory vesicles and discharge of vesicle
contents. Actin and myosin are essential for pre-fusion and post-fusion stages of exocytosis …

This review highlights the complexity of renal epithelial cell membrane architectures and
organelles through careful review of ultrastructural and physiological studies published over …

The physiological function of actin filaments is challenging to dissect because of the
pleiotropic impact of global disruption of the actin cytoskeleton. Tropomyosin isoforms have …

Various forms of cell motility critically depend on pushing, pulling, and resistance forces
generated by the actin cytoskeleton. Whereas pushing forces largely depend on actin …

Blood endothelial cells control the hemostatic and inflammatory response by secreting von
Willebrand factor (VWF) and P-selectin from storage organelles called Weibel-Palade …

Imaging subcellular processes in live animals is no longer a dream. The development of
Intravital Subcellular Microscopy (ISMic) combined with the astounding repertoire of …