Highlights•The reductionist drug discovery approach entails high attrition rates.•Topology-
based pathway analysis can unravel the disease mechanism (s).•Candidate targets can be …

Low drug productivity has been a significant problem of the pharmaceutical industry for
several decades even though numerous novel technologies were introduced during this …

Zika virus (ZIKV) causes microcephaly by killing neural precursor cells (NPCs) and other
brain cells. ZIKV also displays therapeutic oncolytic activity against glioblastoma (GBM) stem …

Background Traumatic brain injury (TBI) is a leading cause of death and disability that lacks
neuroprotective therapies. Following a TBI, secondary injury response pathways are …

Abstract iPathwayGuide is a gene expression analysis tool that provides biological context
and inferences from data generated by high‐throughput sequencing. iPathwayGuide utilizes …

A bottleneck in high-throughput functional genomics experiments is identifying the most
important genes and their relevant functions from a list of gene hits. Gene Ontology (GO) …

One of the hallmarks of intractable psoriasis is neutrophil infiltration in skin lesions.
However, detailed molecular mechanisms of neutrophil chemotaxis and activation remain …

Cross-experiment comparisons in public data compendia are challenged by unmatched
conditions and technical noise. The ADAGE method, which performs unsupervised …

Background Enrichment analysis of gene expression data is essential to find functional
groups of genes whose interplay can explain experimental observations. Numerous …

Elevated airborne PCB levels in older schools are concerning due to their health impacts,
including cancer, metabolic dysfunction-associated steatotic liver disease (MASLD) …