Multiplicity of data, hypotheses, and analyses is a common problem in biomedical and
epidemiological research. Multiple testing theory provides a framework for defining and …

Since 1948, when the World Health Organization defined health as being not only the
absence of disease and infirmity but also the presence of physical, mental, and social well …

Background The PORTEC-3 trial investigated the benefit of combined adjuvant
chemotherapy and radiotherapy versus pelvic radiotherapy alone for women with high-risk …

Background Although women with endometrial cancer generally have a favourable
prognosis, those with high-risk disease features are at increased risk of recurrence. The …

Modern computer-intensive statistical methods play a key role in solving many problems
across a wide range of scientific disciplines. This new edition of the bestselling …

Background Thrombolytic therapy for acute ischemic stroke has been approached
cautiously because there were high rates of intracerebral hemorrhage in early clinical trials …

Objective.—To evaluate the efficacy and safety of intravenous thrombolysis using
recombinant tissue plasminogen activator (rt-PA) in patients with acute ischemic stroke …

Group sequential methods answer the needs of clinical trial monitoring committees who
must assess the data available at an interim analysis. These interim results may provide …

Objective.—To determine whether a nutritional supplement of selenium will decrease the
incidence of cancer. Design.—A multicenter, double-blind, randomized, placebo-controlled …

No single outcome measure can describe or predict all dimensions of recovery and disability
after acute stroke. Several scales have proven reliability and validity in stroke trials …