The term vascular cognitive impairment (VCI) was introduced around the start of the new
millennium and refers to the contribution of vascular pathology to any severity of cognitive …

Melatonin, or 5-methoxy-N-acetyltryptamine, is synthesized and released by the pineal
gland and locally in the retina following a circadian rhythm, with low levels during the day …

Several meta-analyses examining the effects of exercise on depression have been criticized
for including studies of poor methodological integrity. More recent meta-analyses addressed …

Depressive disorders are a significant public health issue. They are prevalent, disabling,
often chronic illnesses, which cause a high economic burden for society, related to both …

Background: A meta-analysis of the efficacy and tolerability of selective serotonin reuptake
inhibitors (SSRIs) against tricyclic antidepressants (TCAs) in depressed patients was carried …

Background Adherence to antidepressant medication use is a problem in clinical practice.
Some authors have posited that combined psychological treatment facilitates adherence to …

The role of modelling in economic evaluation is explored by discussing, with examples, the
uses of models. The expanded use of pragmatic clinical trials as an alternative to models is …

Background Concern has been expressed about the relevance of secondary care studies to
primary care patients specifically about the effectiveness of antidepressant medication …

Weight gain during antidepressant treatment can be either a sign of improvement in patients
who have weight loss as a symptom of depression or a residual symptom in patients who …

OBJECTIVE: Continuation of antidepressant treatment for depression beyond the first
months helps to consolidate treatment response and to reduce the risk of early relapse. The …