How protons pave the way to aggressive cancers
Cancers undergo sequential changes to proton (H+) concentration and sensing that are
consequences of the disease and facilitate its further progression. The impact of protonation …
consequences of the disease and facilitate its further progression. The impact of protonation …
Interactions between hedgehog signaling pathway and the complex tumor microenvironment in breast cancer: current knowledge and therapeutic promises
R Liu, Y Yu, Q Wang, Q Zhao, Y Yao, M Sun… - Cell Communication and …, 2024 - Springer
Breast cancer ranks as one of the most common malignancies among women, with its
prognosis and therapeutic efficacy heavily influenced by factors associated with the tumor …
prognosis and therapeutic efficacy heavily influenced by factors associated with the tumor …
[HTML][HTML] 1, 3, 5-Triazine as a promising scaffold in the development of therapeutic agents against breast cancer
Triazine scaffold has garnered considerable interest due to its wide-ranging
pharmacological properties, particularly in the field of cancer research. Breast cancer is the …
pharmacological properties, particularly in the field of cancer research. Breast cancer is the …
Antibodies toward Na+,HCO3–-cotransporter NBCn1/SLC4A7 block net acid extrusion and cause pH-dependent growth inhibition and apoptosis in breast cancer
TV Axelsen, C Olesen, D Khan, A Mohammadi… - British Journal of …, 2024 - nature.com
Abstract Background Na+, HCO3–-cotransporter NBCn1/Slc4a7 accelerates murine breast
carcinogenesis. Lack of specific pharmacological tools previously restricted therapeutic …
carcinogenesis. Lack of specific pharmacological tools previously restricted therapeutic …
Identifying novel circadian rhythm biomarkers for diagnosis and prognosis of melanoma by an integrated bioinformatics and machine learning approach
Y Xu, C Zeng, J Bin, H Tang, W Li - Aging (Albany NY), 2024 - pmc.ncbi.nlm.nih.gov
Melanoma is a highly malignant skin tumor with poor prognosis. Circadian rhythm is closely
related to melanoma pathogenesis. This study aimed to identify key circadian rhythm genes …
related to melanoma pathogenesis. This study aimed to identify key circadian rhythm genes …
Strengthening the basics: Acids and bases influence vascular structure and function, tissue perfusion, blood pressure, and human cardiovascular disease
E Boedtkjer, T Ara - Pflügers Archiv-European Journal of Physiology, 2024 - Springer
Acids and their conjugate bases accumulate in or dissipate from the interstitial space when
tissue perfusion does not match the metabolic demand. Extracellular acidosis dilates most …
tissue perfusion does not match the metabolic demand. Extracellular acidosis dilates most …
Pantoprazole and riluzole target H+/K+‐ATPases and pH‐sensitive K+ channels in pancreatic cancer cells
G Deshar, NM Christensen… - International Journal of …, 2024 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) remains the most lethal cancer type. PDAC is
characterized by fibrotic, hypoxic, and presumably acidic tumor microenvironment (TME) …
characterized by fibrotic, hypoxic, and presumably acidic tumor microenvironment (TME) …
Acid–base transporters in the context of tumor heterogeneity
SHF Pedersen - Pflügers Archiv-European Journal of Physiology, 2024 - Springer
The copious metabolic acid production and-extrusion by cancer cells render poorly
vascularized regions of solid tumors highly acidic. A growing list of proton-and bicarbonate …
vascularized regions of solid tumors highly acidic. A growing list of proton-and bicarbonate …
Regulation of cancer cell lipid metabolism and oxidative phosphorylation by microenvironmental acidosis
MG Rolver, M Severin… - American Journal of …, 2024 - journals.physiology.org
The expansion of cancer cell mass in solid tumors generates a harsh environment
characterized by dynamically varying levels of acidosis, hypoxia, and nutrient deprivation …
characterized by dynamically varying levels of acidosis, hypoxia, and nutrient deprivation …
Association of the bitter taste genes TAS2R38 and CA6 and breast cancer risk; a case-control study of Polish women in Poland and Polish immigrants in USA
D Łukasiewicz-Śmietańska, D Godlewski… - Plos one, 2024 - journals.plos.org
It is known that the perception of bitterness is mediated by type 2 bitter taste receptors
(TAS2Rs). However, recent reports have suggested that the carbonic anhydrase 6 (CA6) …
(TAS2Rs). However, recent reports have suggested that the carbonic anhydrase 6 (CA6) …