Major depression is one of the leading causes of disability, morbidity, and mortality
worldwide. The brain–gut axis functions are disturbed, revealed by a dysfunction of the …

Major depressive disorder (MDD) is a common emotional cognitive disorder that seriously
affects people's physical and mental health and their quality of life. Due to its clinical and …

Background Microglial activation-mediated neuroinflammation is one of the essential
pathogenic mechanisms of sepsis-associated encephalopathy (SAE). Mounting evidence …

Major depressive disorder (MDD) is the most prevalent psychiatric disorder worldwide and
severely limits psychosocial function and quality of life, but no effective medication is …

Rationale The chronic mild stress (CMS) paradigm was first described almost 40 years ago
and has become a widely used model in the search for antidepressant drugs for major …

Microglia are so versatile that they not only provide immune surveillance for central nervous
system, but participate in neural circuitry development, brain blood vessels formation, blood …

Chronic stress is a key risk factor for depression, and microglia have been implicated in the
pathogenesis of the disease. Recent studies show that the Nod-like receptor protein 3 …

Chronic stress manifests as depressive-and anxiety-like behavior while recurrent stress
elicits disproportionate behavioral impairments linked to stress-induced immunological …

Major depressive disorder (MDD) is a debilitating neuropsychological disorder, which has
caused serious health and socio-economic burdens worldwide. A growing body of evidence …

Chronic psychosocial stress is increasingly being recognised as a risk factor for sporadic
Alzheimer's disease (AD). The hypothalamic–pituitary–adrenal axis (HPA axis) is the major …