Major reactive oxygen species (ROS)–producing systems in vascular wall include NADPH
(reduced form of nicotinamide adenine dinucleotide phosphate) oxidase, xanthine oxidase …

Vascular disease and heart failure impart an enormous burden in terms of global morbidity
and mortality. Although there are many different causes of cardiac and vascular disease …

Galectin-3 (Gal-3) is a β-galactoside-binding protein belonging to the lectin family with
pleiotropic regulatory activities and several physiological cellular functions, such as cellular …

In the vascular wall, reactive oxygen species (ROS) are produced by several enzyme
systems including NADPH oxidase, xanthine oxidase, uncoupled endothelial nitric oxide …

The paraoxonase (PON) gene family is composed of three members (PON1, PON2, PON3)
that share considerable structural homology and are located adjacently on chromosome 7 in …

Oxidative stress is generated by the imbalance between reactive oxygen species (ROS)
formation and antioxidant scavenger system's activity. Increased ROS, such as superoxide …

Fueled by the global surge in aging, atherosclerotic cardiovascular disease reached
pandemic dimensions putting affected individuals at enhanced risk of myocardial infarction …

Cancer and atherosclerosis are major causes of death in western societies. Deregulated cell
death is common to both diseases, with significant contribution of inflammatory processes …

Oxidative stress and inflammation of the vessel wall contribute to prothrombotic states. The
antioxidative protein paraoxonase-2 (PON2) shows reduced expression in human …

Both mouse and human studies have demonstrated the antioxidative and atheroprotective
effects of PON1. The mechanisms by which PON2 exerts its atheroprotective effects are …