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On virus growth and form
We review approaches aimed at deciphering the physical mechanisms responsible for viral
structure and assembly. We discuss the basic principles of condensed matter physics …
structure and assembly. We discuss the basic principles of condensed matter physics …
Single-molecule experiments in biological physics: methods and applications
I review single-molecule experiments (SMEs) in biological physics. Recent technological
developments have provided the tools to design and build scientific instruments of high …
developments have provided the tools to design and build scientific instruments of high …
The structure and physical properties of a packaged bacteriophage particle
A string of nucleotides confined within a protein capsid contains all the instructions
necessary to make a functional virus particle, a virion. Although the structure of the protein …
necessary to make a functional virus particle, a virion. Although the structure of the protein …
Dense packings of the Platonic and Archimedean solids
Dense particle packings have served as useful models of the structures of liquid, glassy and
crystalline states of matter,,,, granular media,, heterogeneous materials and biological …
crystalline states of matter,,,, granular media,, heterogeneous materials and biological …
50th Anniversary Perspective: Polymer ConformationA Pedagogical Review
The study of the conformation properties of macromolecules is at the heart of polymer
science. Essentially all physical properties of polymers are manifestations of the underlying …
science. Essentially all physical properties of polymers are manifestations of the underlying …
Bacteriophage capsids: tough nanoshells with complex elastic properties
The shell of bacteriophages protects the viral DNA during host-to-host transfer and serves as
a high-pressure container storing energy for DNA injection into a host bacterium. Here, we …
a high-pressure container storing energy for DNA injection into a host bacterium. Here, we …
Viruses' life history: towards a mechanistic basis of a trade-off between survival and reproduction among phages
Life history theory accounts for variations in many traits involved in the reproduction and
survival of living organisms, by determining the constraints leading to trade-offs among …
survival of living organisms, by determining the constraints leading to trade-offs among …
[HTML][HTML] Spontaneous sharp bending of double-stranded DNA
TE Cloutier, J Widom - Molecular cell, 2004 - cell.com
Sharply bent DNA is essential for gene regulation in prokaryotes and is a major feature of
eukaryotic nucleosomes and viruses. The explanation normally given for these phenomena …
eukaryotic nucleosomes and viruses. The explanation normally given for these phenomena …
Osmotic pressure inhibition of DNA ejection from phage
Bacterial viral capsids in aqueous solution can be opened in vitro by addition of their specific
receptor proteins, with consequent full ejection of their genomes. We demonstrate that it is …
receptor proteins, with consequent full ejection of their genomes. We demonstrate that it is …
[HTML][HTML] Forces during bacteriophage DNA packaging and ejection
The conjunction of insights from structural biology, solution biochemistry, genetics, and
single-molecule biophysics has provided a renewed impetus for the construction of …
single-molecule biophysics has provided a renewed impetus for the construction of …