Introduction Debate continues over the precise causal contribution made by mesolimbic
dopamine systems to reward. There are three competing explanatory categories:'liking' …

The mesolimbic dopaminergic (ML-DA) system has been recognized for its central role in
motivated behaviors, various types of reward, and, more recently, in cognitive processes …

Ventral tegmental area (VTA) neuron firing precedes behaviors elicited by reward-predictive
sensory cues and scales with the magnitude and unpredictability of received rewards. These …

Work over the past decade has supported the idea that discrete aspects of appetitive
motivation are differentially mediated by separate but interacting neurochemical systems …

Huntington's disease (HD) is caused by an expansion of cytosine–adenine–guanine (CAG)
repeats in the huntingtin gene, which leads to neuronal loss in the striatum and cortex and to …

Here we challenge the view that reward‐guided learning is solely controlled by the
mesoaccumbens pathway arising from dopaminergic neurons in the ventral tegmental area …

Background The nucleus accumbens is the ventral extent of the striatum, the main input
nucleus of the basal ganglia. Recent hypotheses propose that the accumbens and its …

Background and objectives The idea that nucleus accumbens (Acb) dopamine transmission
contributes to the neural mediation of reward, at least in a general sense, has achieved wide …

The striatum can be divided into dorsal (caudate-putamen) and ventral parts. In the ventral
division, the nucleus accumbens, which subserves adaptive and goal-directed behaviors, is …

Sex differences have complicated our understanding of the neurobiological basis of many
behaviors that are key for survival. As such, continued elucidation of the similarities and …