Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Omics technologies have rapidly evolved with the unprecedented potential to shape
precision medicine. Novel omics approaches are imperative toallow rapid and accurate data …

Reactive oxygen species (ROS) are important in regulating normal cellular processes
whereas deregulated ROS leads to the development of a diseased state in humans …

Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction
pathways that regulate all aspects of life and are frequently altered in disease. Here, we …

Cancer is the second leading cause of death in the US. Current major treatments for cancer
management include surgery, cytotoxic chemotherapy, targeted therapy, radiation therapy …

Simple Summary The deregulation of the oxidative metabolism in cancer cells,
characterized by an increased ratio between glycolysis and oxygen consumption (Warburgv …

Mitochondria are indispensable for energy metabolism, apoptosis regulation, and cell
signaling. Mitochondria in malignant cells differ structurally and functionally from those in …

Aberrant activation of the PI3K/Akt pathway commonly occurs in cancers and correlates with
multiple aspects of malignant progression. In particular, recent evidence suggests that the …

The role of reactive oxygen species (ROS) in cancer cells has been intensively studied for
the past two decades. Cancer cells mostly have higher basal ROS levels than their normal …

Bioluminescence (BL) is a spectacular phenomenon involving light emission by live
organisms. It is caused by the oxidation of a small organic molecule, luciferin, with molecular …