Objectives To synthesise research investigating data and code sharing in medicine and
health to establish an accurate representation of the prevalence of sharing, how this …

Despite many studies of the likely survival outcome of individual patients with colorectal
cancer, our knowledge of this subject remains poor. Until recently, we had virtually no …

Precision medicine is critically dependent on better methods for diagnosing and staging
disease and predicting drug response. Histopathology using hematoxylin and eosin (H&E) …

Abstract Background The Reporting Recommendations for Tumor Marker Prognostic
Studies (REMARK) checklist consists of 20 items to report for published tumor marker …

There is increasing concern that most current published research findings are false. The
probability that a research claim is true may depend on study power and bias, the number of …

Background Genome-wide measures of gene expression can identify patterns of gene
activity that subclassify tumours and might provide a better means than is currently available …

ContextControversy and uncertainty ensue when the results of clinical research on the
effectiveness of interventions are subsequently contradicted. Controversies are most …

Abstract Animals Breast Neoplasms-diagnosis Breast Neoplasms-genetics Disease Models,
Animal Female Gene Expression Profiling-methods Gene Expression Profiling-standards …

Background Sharing research data provides benefit to the general scientific community, but
the benefit is less obvious for the investigator who makes his or her data available. Principal …

Many metabolomics, and other high-content or high-throughput, experiments are set up
such that the primary aim is the discovery of biomarker metabolites that can discriminate …