Recent breakthroughs in tumor immunotherapy such as immune checkpoint blockade (ICB)
antibodies, have demonstrated the capacity of the immune system to fight cancer in a …

Simple Summary It was found that long-established tumor-derived cell lines do not
adequately reproduce drug sensitivity and behavior of a real human cancers. Therefore …

Drug development in oncology commonly exploits the tools of molecular biology to gain
therapeutic benefit through reprograming of cellular responses. In immuno‐oncology (IO) …

More and more evidences show that macrophages can induce both pro-tumor and anti-
tumor effects. The study on genetically engineered macrophages to kill tumor cells has …

Macrophages' role in the evolution of solid tumours is a well accepted fact, with the M1-like
macrophages having an anti-tumour role and the M2-like macrophages having a pro-tumour …

The development of new techniques for anti-cancer therapy has become a very active area
of research in recent years. One of the promising directions of anti-cancer therapy aims at …

Anti-cancer therapies based on oncolytic viruses are emerging as important approaches in
cancer treatment. However, the effectiveness of these therapies depends significantly on the …

Melanoma is the most aggressive and deadly form of skin cancer, and its incidence has
been steadily increasing over the past few decades, particularly in the Caucasian …

Abstract Non Small Cell Lung Cancer (NSCLC) is the most common type of lung cancer, and
represents the leading cause of cancer-related deaths worldwide. Experimental studies …

The heterogeneity and plasticity of macrophages have become a topic of great interest, due
to their role in various diseases ranging from cancer to bacterial infections. While initial …