Modern techniques in molecular biology, genomics, and mass spectrometry–based
proteomics have identified a large number of novel histone posttranslational modifications …

Histone posttranslational modifications are key components of diverse processes that
modulate chromatin structure. These marks function as signals during various chromatin …

Double-strand breaks (DSBs) are extremely detrimental DNA lesions that can lead to cancer-
driving mutations and translocations. Non-homologous end joining (NHEJ) and homologous …

The surface of nucleosomes is studded with a multiplicity of modifications. At least eight
different classes have been characterized to date and many different sites have been …

Several mechanisms have been proposed for histone marks to exert their functions,
including altering the physical properties of nucleosomes by neutralization of charge via …

Now in its twelfth edition, Lewin's GENES continues to lead with new information and cutting-
edge developments, covering gene structure, sequencing, organization, and expression …

In response to even a single chromosomal double-strand DNA break, cells enact the DNA
damage checkpoint. This checkpoint triggers cell cycle arrest, providing time for the cell to …

Minutes after DNA damage, the variant histone H2AX is phosphorylated by protein kinases
of the phosphoinositide kinase family, including ATM, ATR or DNA-PK. Phosphorylated (γ) …

Nonhomologous end joining (NHEJ), the direct rejoining of DNA double-strand breaks, is
closely associated with illegitimate recombination and chromosomal rearrangement. This …

Although discovered long ago, posttranslational phosphorylation of histones has been in the
spotlight only recently. Information is accumulating almost daily on phosphorylation of …