Metabolic modulation in macrophage effector function

C Diskin, EM Pålsson-McDermott - Frontiers in immunology, 2018 - frontiersin.org
Traditionally cellular respiration or metabolism has been viewed as catabolic and anabolic
pathways generating energy and biosynthetic precursors required for growth and general …

Toxic dimethylarginines: asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA)

YL Tain, CN Hsu - Toxins, 2017 - mdpi.com
Asymmetric and symmetric dimethylarginine (ADMA and SDMA, respectively) are toxic, non-
proteinogenic amino acids formed by post-translational modification and are uremic toxins …

Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma

JL Rubenstein, H Geng, EJ Fraser, P Formaker… - Blood …, 2018 - ashpublications.org
There is an unmet need for effective biological therapies for relapsed central nervous system
(CNS) lymphoma. Lenalidomide is active in activated B-cell type diffuse large B-cell …

A water-soluble boronate-based fluorescent probe for the selective detection of peroxynitrite and imaging in living cells

X Sun, Q Xu, G Kim, SE Flower, JP Lowe, J Yoon… - Chemical …, 2014 - pubs.rsc.org
A water-soluble boronate-based fluorescent probe was evaluated for the detection of
peroxynitrite (ONOO−) in the presence of a monosaccharide. The enhanced fluorescence of …

A systematic review and meta-analysis of the effect of statins on plasma asymmetric dimethylarginine concentrations

C Serban, A Sahebkar, S Ursoniu, DP Mikhailidis… - Scientific reports, 2015 - nature.com
The impact of statin therapy on plasma asymmetric dimethylarginine (ADMA) levels has not
been conclusively studied. Therefore the aim of the meta-analysis was to assess the effect of …

ADMA: a key player in the relationship between vascular dysfunction and inflammation in atherosclerosis

L Dowsett, E Higgins, S Alanazi… - Journal of Clinical …, 2020 - mdpi.com
Atherosclerosis is a chronic cardiovascular disease which increases risk of major
cardiovascular events including myocardial infarction and stroke. Elevated plasma …

Dimethylarginine dimethylaminohydrolase 1 protects PM2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress

J Gao, T Lei, H Wang, K Luo, Y Wang, B Cui… - Particle and Fibre …, 2022 - Springer
Background Airborne fine particulate matter with aerodynamic diameter≤ 2.5 μm (PM2. 5)
pollution is associated with the prevalence of respiratory diseases, including asthma …

Systems approach to discovery of therapeutic targets for vein graft disease: PPARα pivotally regulates metabolism, activation, and heterogeneity of macrophages and …

JL Decano, SA Singh, C Gasparotto Bueno, L Ho Lee… - Circulation, 2021 - Am Heart Assoc
Background: Vein graft failure remains a common clinical challenge. We applied a systems
approach in mouse experiments to discover therapeutic targets for vein graft failure …

Nitro-oleic acid modulates classical and regulatory activation of macrophages and their involvement in pro-fibrotic responses

G Ambrozova, H Martiskova, A Koudelka… - Free Radical Biology …, 2016 - Elsevier
Inflammation is an immune response triggered by microbial invasion and/or tissue injury.
While acute inflammation is directed toward invading pathogens and injured cells, thus …

A multi-platform metabolomics approach identifies urinary metabolite signatures that differentiate ketotic from healthy dairy cows

G Zhang, R Mandal, DS Wishart… - Frontiers in Veterinary …, 2021 - frontiersin.org
Ketosis and subclinical ketosis are widespread among dairy cows especially after calving.
Etiopathology of ketosis has been related to negative energy balance. The objective of this …