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Metabolic modulation in macrophage effector function
C Diskin, EM Pålsson-McDermott - Frontiers in immunology, 2018 - frontiersin.org
Traditionally cellular respiration or metabolism has been viewed as catabolic and anabolic
pathways generating energy and biosynthetic precursors required for growth and general …
pathways generating energy and biosynthetic precursors required for growth and general …
Toxic dimethylarginines: asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA)
Asymmetric and symmetric dimethylarginine (ADMA and SDMA, respectively) are toxic, non-
proteinogenic amino acids formed by post-translational modification and are uremic toxins …
proteinogenic amino acids formed by post-translational modification and are uremic toxins …
Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma
JL Rubenstein, H Geng, EJ Fraser, P Formaker… - Blood …, 2018 - ashpublications.org
There is an unmet need for effective biological therapies for relapsed central nervous system
(CNS) lymphoma. Lenalidomide is active in activated B-cell type diffuse large B-cell …
(CNS) lymphoma. Lenalidomide is active in activated B-cell type diffuse large B-cell …
A water-soluble boronate-based fluorescent probe for the selective detection of peroxynitrite and imaging in living cells
A water-soluble boronate-based fluorescent probe was evaluated for the detection of
peroxynitrite (ONOO−) in the presence of a monosaccharide. The enhanced fluorescence of …
peroxynitrite (ONOO−) in the presence of a monosaccharide. The enhanced fluorescence of …
A systematic review and meta-analysis of the effect of statins on plasma asymmetric dimethylarginine concentrations
C Serban, A Sahebkar, S Ursoniu, DP Mikhailidis… - Scientific reports, 2015 - nature.com
The impact of statin therapy on plasma asymmetric dimethylarginine (ADMA) levels has not
been conclusively studied. Therefore the aim of the meta-analysis was to assess the effect of …
been conclusively studied. Therefore the aim of the meta-analysis was to assess the effect of …
ADMA: a key player in the relationship between vascular dysfunction and inflammation in atherosclerosis
L Dowsett, E Higgins, S Alanazi… - Journal of Clinical …, 2020 - mdpi.com
Atherosclerosis is a chronic cardiovascular disease which increases risk of major
cardiovascular events including myocardial infarction and stroke. Elevated plasma …
cardiovascular events including myocardial infarction and stroke. Elevated plasma …
Dimethylarginine dimethylaminohydrolase 1 protects PM2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress
J Gao, T Lei, H Wang, K Luo, Y Wang, B Cui… - Particle and Fibre …, 2022 - Springer
Background Airborne fine particulate matter with aerodynamic diameter≤ 2.5 μm (PM2. 5)
pollution is associated with the prevalence of respiratory diseases, including asthma …
pollution is associated with the prevalence of respiratory diseases, including asthma …
Systems approach to discovery of therapeutic targets for vein graft disease: PPARα pivotally regulates metabolism, activation, and heterogeneity of macrophages and …
JL Decano, SA Singh, C Gasparotto Bueno, L Ho Lee… - Circulation, 2021 - Am Heart Assoc
Background: Vein graft failure remains a common clinical challenge. We applied a systems
approach in mouse experiments to discover therapeutic targets for vein graft failure …
approach in mouse experiments to discover therapeutic targets for vein graft failure …
Nitro-oleic acid modulates classical and regulatory activation of macrophages and their involvement in pro-fibrotic responses
G Ambrozova, H Martiskova, A Koudelka… - Free Radical Biology …, 2016 - Elsevier
Inflammation is an immune response triggered by microbial invasion and/or tissue injury.
While acute inflammation is directed toward invading pathogens and injured cells, thus …
While acute inflammation is directed toward invading pathogens and injured cells, thus …
A multi-platform metabolomics approach identifies urinary metabolite signatures that differentiate ketotic from healthy dairy cows
Ketosis and subclinical ketosis are widespread among dairy cows especially after calving.
Etiopathology of ketosis has been related to negative energy balance. The objective of this …
Etiopathology of ketosis has been related to negative energy balance. The objective of this …