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Nuclear hormone receptors and gene expression
A Aranda, A Pascual - Physiological reviews, 2001 - journals.physiology.org
The nuclear hormone receptor superfamily includes receptors for thyroid and steroid
hormones, retinoids and vitamin D, as well as different “orphan” receptors of unknown …
hormones, retinoids and vitamin D, as well as different “orphan” receptors of unknown …
Epigenetics: a molecular link between environmental factors and type 2 diabetes
Although obesity, reduced physical activity, and aging increase susceptibility to type 2
diabetes, many people exposed to these risk factors do not develop the disease. Recent …
diabetes, many people exposed to these risk factors do not develop the disease. Recent …
Transcription factors in liver development, differentiation, and regeneration
Transcriptional Activation. The liver performs essential functions in the body by uniquely
expressing hepatocyte-specific genes encoding plasma proteins, clotting factors and …
expressing hepatocyte-specific genes encoding plasma proteins, clotting factors and …
Histone acetylation and disease
S Timmermann, H Lehrmann, A Polesskaya… - Cellular and Molecular …, 2001 - Springer
Differential acetylation of histones and transcription factors plays an important regulatory
role in developmental processes, proliferation and differentiation. Aberrant acetylation or …
role in developmental processes, proliferation and differentiation. Aberrant acetylation or …
[HTML][HTML] Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration
Hepatic uptake and biliary excretion of organic anions (eg, bile acids and bilirubin) is
mediated by hepatobiliary transport systems. Defects in transporter expression and function …
mediated by hepatobiliary transport systems. Defects in transporter expression and function …
Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant β cells
Heterozygous HNF1A gene mutations can cause maturity onset diabetes of the young 3
(MODY3), characterized by insulin secretion defects. However, specific mechanisms of …
(MODY3), characterized by insulin secretion defects. However, specific mechanisms of …
Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV
Activity-regulated transcription has been implicated in adaptive plasticity in the CNS. In
many instances, this plasticity depends upon the transcription factor CREB. Precisely how …
many instances, this plasticity depends upon the transcription factor CREB. Precisely how …
p300 acts as a transcriptional coactivator for mammalian Notch-1
Notch-1 belongs to a family of transmembrane receptor proteins that direct the decisions as
to various cell fates. After ligand binding, a proteolytic cleavage step occurs and the …
to various cell fates. After ligand binding, a proteolytic cleavage step occurs and the …
Liver-enriched transcription factors in liver function and development. Part I: the hepatocyte nuclear factor network and liver-specific gene expression
Numerous studies have established the pivotal role of liver-enriched transcription factors in
organ development and cellular function, and there is conclusive evidence for transcription …
organ development and cellular function, and there is conclusive evidence for transcription …
HNF1A mutations and beta cell dysfunction in diabetes
Understanding the genetic factors of diabetes is essential for addressing the global increase
in type 2 diabetes. HNF1A mutations cause a monogenic form of diabetes called maturity …
in type 2 diabetes. HNF1A mutations cause a monogenic form of diabetes called maturity …