The resistance of cancer cells to chemotherapeutic drugs greatly reduces the therapeutic
effect in cancer patients, and the toxic side effects caused by chemotherapy also seriously …

Colorectal cancer is one of the leading causes of morbidity and mortality globally, which
accounts for 0.7 million deaths in 2015. Despite the fact that tremendous advancement had …

Inflammatory bowel disease (IBD) is a recurrent chronic intestinal disorder that includes
ulcerative colitis (UC) and Crohn's disease (CD). Its pathogenesis involves intricate …

Prior to the advent of genetic engineering in the mouse, the rat was the model of choice for
investigating the etiology of cancer. Now, recent advances in the manipulation of the rat …

Abstract Background Epigallocatechin-3-gallate (EGCG), the primary active compound in
green tea, is recognized for its significant anti-inflammatory properties and potential …

FXR is a member of the nuclear receptor superfamily and bile acids are endogenous ligands
of FXR. FXR activation has recently been reported to inhibit intestinal inflammation and …

The mechanisms of action of polyphenols have attracted much attention. Catechins are
generally known as tea polyphenols. Researchers have extensively investigated the …

Species differences in the metabolism of xenobiotics by cytochrome P450 are critical in
evaluating the use of experimental animals in studying toxic compounds relevant to human …

Colorectal cancer affects a large number of people. There is an urgent need to develop
novel treatments for this disease. In recent years, research on medical applications of …

Chronic inflammation in the colorectum increases the risk of colorectal cancer development.
Pentoxifylline, a medicine used for improving the circulation, has been reported to inhibit …