Approaches to revealing the neural basis of muscle synergies: a review and a critique

VCK Cheung, K Seki - Journal of neurophysiology, 2021 - journals.physiology.org
The central nervous system (CNS) may produce coordinated motor outputs via the
combination of motor modules representable as muscle synergies. Identification of muscle …

Motor neurons generate pose-targeted movements via proprioceptive sculpting

B Gorko, I Siwanowicz, K Close, C Christoforou… - Nature, 2024 - nature.com
Motor neurons are the final common pathway through which the brain controls movement of
the body, forming the basic elements from which all movement is composed. Yet how a …

From motor planning to execution: a sensorimotor loop perspective

E Bizzi, R Ajemian - Journal of Neurophysiology, 2020 - journals.physiology.org
How is an evanescent wish to move translated into a concrete action? This simple question
and puzzling miracle remains a focal point of motor systems neuroscience. Where does the …

Plasticity of muscle synergies through fractionation and merging during development and training of human runners

VCK Cheung, BMF Cheung, JH Zhang… - Nature …, 2020 - nature.com
Complex motor commands for human locomotion are generated through the combination of
motor modules representable as muscle synergies. Recent data have argued that muscle …

Sar: Generalization of physiological agility and dexterity via synergistic action representation

C Berg, V Caggiano, V Kumar - Autonomous Robots, 2024 - Springer
Learning effective continuous control policies in high-dimensional systems, including
musculoskeletal agents, remains a significant challenge. Over the course of biological …

Myodex: a generalizable prior for dexterous manipulation

V Caggiano, S Dasari, V Kumar - … Conference on Machine …, 2023 - proceedings.mlr.press
Human dexterity is a hallmark of motor control behaviors. Our hands can rapidly synthesize
new behaviors despite the complexity (multi-articular and multi-joints, with 23 joints …

The corticospinal tract primarily modulates sensory inputs in the mouse lumbar cord

Y Moreno-Lopez, C Bichara, G Delbecq, P Isope… - Elife, 2021 - elifesciences.org
It is generally assumed that the main function of the corticospinal tract (CST) is to convey
motor commands to bulbar or spinal motoneurons. Yet the CST has also been shown to …

Spinal control of muscle synergies for adult mammalian locomotion

E Desrochers, J Harnie, A Doelman… - The Journal of …, 2019 - Wiley Online Library
Key points The control of locomotion is thought to be generated by activating groups of
muscles that perform similar actions, which are termed muscle synergies. Here, we …

Altered baseline and nicotine-mediated behavioral and cholinergic profiles in ChAT-Cre mouse lines

E Chen, V Lallai, Y Sherafat, NP Grimes… - Journal of …, 2018 - jneurosci.org
The recent development of transgenic rodent lines expressing cre recombinase in a cell-
specific manner, along with advances in engineered viral vectors, has permitted in-depth …

Robot-driven locomotor perturbations reveal synergy-mediated, context-dependent feedforward and feedback mechanisms of adaptation

G Severini, A Koenig, C Adans-Dester, I Cajigas… - Scientific reports, 2020 - nature.com
Humans respond to mechanical perturbations that affect their gait by changing their motor
control strategy. Previous work indicates that adaptation during gait is context dependent …