Carbon ion radiobiology

W Tinganelli, M Durante - Cancers, 2020 - mdpi.com
Simple Summary Radiotherapy with carbon ions has been used for over 20 years in Asia
and Europe and is now planned in the USA. The physics advantages of carbon ions …

Physics and biomedical challenges of cancer therapy with accelerated heavy ions

M Durante, J Debus, JS Loeffler - Nature Reviews Physics, 2021 - nature.com
Radiotherapy should have low toxicity in the entrance channel (normal tissue) and be very
effective in cell killing in the target region (tumour). In this regard, ions heavier than protons …

[HTML][HTML] Spatially fractionated radiation therapy: History, present and the future

W Yan, MK Khan, X Wu, CB Simone II, J Fan… - Clinical and translational …, 2020 - Elsevier
Spatially Fractionated Radiation therapy (SFRT) has a history of over 100 years. The
principle of SFRT is distinctive from the standard radiation approaches, as it treats the total …

Radiation-induced bystander signalling in cancer therapy

KM Prise, JM O'sullivan - Nature Reviews Cancer, 2009 - nature.com
Our understanding of how radiation kills normal and tumour cells has been based on an
intimate knowledge of the direct induction of DNA damage and its cellular consequences …

Understanding high-dose, ultra-high dose rate, and spatially fractionated radiation therapy

RJ Griffin, MM Ahmed, B Amendola, O Belyakov… - International Journal of …, 2020 - Elsevier
The National Cancer Institute's Radiation Research Program, in collaboration with the
Radiosurgery Society, hosted a workshop called Understanding High-Dose, Ultra-High …

Proton minibeam radiation therapy spares normal rat brain: Long-Term Clinical, Radiological and Histopathological Analysis

Y Prezado, G Jouvion, D Hardy, A Patriarca… - Scientific reports, 2017 - nature.com
Proton minibeam radiation therapy (pMBRT) is a novel strategy for minimizing normal tissue
damage resulting from radiotherapy treatments. This strategy partners the inherent …

Proton minibeam radiation therapy widens the therapeutic index for high-grade gliomas

Y Prezado, G Jouvion, A Patriarca, C Nauraye… - Scientific reports, 2018 - nature.com
Proton minibeam radiation therapy (pMBRT) is a novel strategy which has already shown a
remarkable reduction in neurotoxicity as to compared with standard proton therapy. Here we …

Effects of pulsed, spatially fractionated, microscopic synchrotron X-ray beams on normal and tumoral brain tissue

E Bräuer-Krisch, R Serduc, EA Siegbahn… - … Research/Reviews in …, 2010 - Elsevier
Microbeam radiation therapy (MRT) uses highly collimated, quasi-parallel arrays of X-ray
microbeams of 50–600keV, produced by third generation synchrotron sources, such as the …

Divide and conquer: spatially fractionated radiation therapy

Y Prezado - Expert reviews in molecular medicine, 2022 - cambridge.org
Spatially fractionated radiation therapy (SFRT) challenges some of the classical dogmas in
conventional radiotherapy. The highly modulated spatial dose distributions in SFRT have …

Proton‐minibeam radiation therapy: a proof of concept

Y Prezado, GR Fois - Medical physics, 2013 - Wiley Online Library
Purpose: This Monte Carlo simulation work aims at studying a new radiotherapy approach
called proton‐minibeam radiation therapy (pMBRT). The main objective of this proof of …