Noncoding RNAs (ncRNAs) accomplish a remarkable variety of biological functions. They
regulate gene expression at the levels of transcription, RNA processing, and translation …

RNA-based therapies, including RNA molecules as drugs and RNA-targeted small
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …

Proteins and their functional interactions form the backbone of the cellular machinery. Their
connectivity network needs to be considered for the full understanding of biological …

The human genome holds an extraordinary trove of information about human development,
physiology, medicine and evolution. Here we report the results of an international …

Self-assembly is the autonomous organization of components into patterns or structures
without human intervention. Self-assembling processes are common throughout nature and …

Evaluation of the electrostatic properties of biomolecules has become a standard practice in
molecular biophysics. Foremost among the models used to elucidate the electrostatic …

Precise knowledge of the structure of macromolecules in the cell is essential for
understanding how they function. Structures of large macromolecules can now be obtained …

Antimicrobial agents play a key role in controlling and curing infectious disease. Soon after
the discovery of the first antibiotic, the challenge of antibiotic resistance commenced …

Recognition of the natural abundance and functional importance of intrinsically disordered
proteins (IDPs), and protein hybrids that contain both intrinsically disordered protein regions …

Based on fundamental chemistry, biotechnology and materials science have developed
over the past three decades into today's powerful disciplines which allow the engineering of …