Diagnosis of neurological and psychiatric conditions associated with disturbances of
dopaminergic functioning can be challenging, especially in the early stages, and may be …

Abstract Background Accurate diagnosis of Parkinson disease (PD) and other degenerative
parkinsonian syndromes is important for management and prognostic purposes. Diagnosis …

GTP cyclohydrolase 1, encoded by the GCH1 gene, is an essential enzyme for dopamine
production in nigrostriatal cells. Loss-of-function mutations in GCH1 result in severe …

The circuit changes that mediate parkinsonian tremor, while likely differing from those
underlying akinesia and rigidity, are not precisely known. In this study, to identify a specific …

Background: The pathophysiology underlying essential tremor (ET) still is poorly
understood. Recent research suggests a pivotal role of the cerebellum in tremor genesis …

Essential tremor (ET) and Parkinson's disease (PD) are the two most common tremor
disorders encountered in a movement disorders clinic. Although distinct clinical-pathological …

Introduction Although clinician-based assessment through standardized clinical rating
scales is currently the gold standard for quantifying motor impairment in Parkinson's disease …

In specialized movement disorder centers, Parkinson's disease (PD) is wrongly diagnosed
in 6 to 25% of cases. To improve the accuracy of the clinical diagnosis, it is necessary to …

Background Essential tremor is regarded to be a disease of the central nervous system.
Neuroimaging is a rapidly growing field with potential benefits to both diagnostics and …

Early and accurate diagnosis of Parkinson's disease (PD) is important for early
management, proper prognostication and for initiating neuroprotective therapies once they …