European expansion and contact with indigenous populations led to catastrophic
depopulation primarily through the introduction of novel infectious diseases to which native …

Background The role of interferon-gamma (IFN-γ) in autoimmune disorders has been well
documented. Elevated levels of IFN-γ are observed in rheumatoid arthritis (RA) and systemic …

Background Interferon-γ (IFN-γ) plays an important role in the control of Leishmania
infection. Blockade of IFN-γ signaling in mice increases lesion size and parasite load. In …

Coronavirus disease 2019 (COVID-19) is an infection characterized by the dysregulation of
systemic cytokine levels. The measurement of serum levels of inflammatory cyto …

ABSTRACT Interleukin-10 (IL-10)-producing regulatory B (Breg) cells were found to be
induced in a variety of infectious diseases. However, its importance in the regulation of …

Metabolic syndrome (MetS) is an inflammatory disorder, in which various cytokines play
important role in tilting balance towards disease state. Interleukin-10 (IL-10) is an important …

Background: Irritable bowel syndrome (IBS), a functional gastrointestinal disorder, is
characterized by cytokine imbalance. Previously, decreased plasma interleukin 10 (IL-10) …

Susceptibility to severe influenza A/H1N1pdm09 virus is multifactorial. The present study
was carried out in 246 patients infected with A/H1N1pdm09 virus to find out whether single …

Paracoccidioidomycosis (PCM) is a systemic chronic mycosis, endemic in Latin America,
especially Brazil, and is the eighth leading cause of death among chronic and recurrent …

Polymorphisms in cytokine genes can alter the production of these proteins and
consequently affect the immune response. The trihybrid heterogeneity of the Brazilian …