Dissemination and prevalence of plasmid-mediated high-level tigecycline resistance gene tet (X4)

S Zhang, J Wen, Y Wang, M Wang, R Jia… - Frontiers in …, 2022 - frontiersin.org
With the large-scale use of antibiotics, antibiotic resistant bacteria (ARB) continue to rise,
and antibiotic resistance genes (ARGs) are regarded as emerging environmental pollutants …

Multidrug-resistant Klebsiella pneumoniae: mechanisms of resistance including updated data for novel β-lactam-β-lactamase inhibitor combinations

I Galani, I Karaiskos, H Giamarellou - Expert Review of Anti …, 2021 - Taylor & Francis
ABSTRACT Introduction: Multi-drug-resistant Klebsiella pneumoniae is currently one of the
most pressing emerging issues in bacterial resistance. Treatment of K. pneumoniae …

Metagenomic insight into microbiome and antibiotic resistance genes of high clinical concern in urban and rural hospital wastewater of northern India origin: a major …

A Talat, KS Blake, G Dantas, AU Khan - Microbiology spectrum, 2023 - journals.asm.org
India is one of the largest consumers and producers of antibiotics and a hot spot for the
emergence and proliferation of antimicrobial resistance genes (ARGs). Indian hospital …

Persistence and potential risks of tetracyclines and their transformation products in two typical different animal manure composting treatments

D Wu, S Dai, H Feng, SHPP Karunaratne, M Yang… - Environmental …, 2024 - Elsevier
Abundant residues of tetracyclines in animal manures and manure-derived organic
fertilizers can pose a substantial risk to environments. However, our knowledge on the …

Sequence-structure-function characterization of the emerging tetracycline destructase family of antibiotic resistance enzymes

KS Blake, H Kumar, A Loganathan, EE Williford… - Communications …, 2024 - nature.com
Tetracycline destructases (TDases) are flavin monooxygenases which can confer resistance
to all generations of tetracycline antibiotics. The recent increase in the number and diversity …

Abundance of tigecycline resistance genes and association with antibiotic residues in Chinese livestock farms

Y Fu, Y Chen, D Liu, D Yang, Z Liu, Y Wang… - Journal of Hazardous …, 2021 - Elsevier
The discovery of plasmid-mediated tet (X) variants and efflux pump gene tmexCD1-toprJ1
conferring bacteria resistance to tigecycline has compromised glycylcycline as the last line …

Mobile genetic elements affect the dissemination of antibiotic resistance genes (ARGs) of clinical importance in the environment

Y Li, R Li, J Hou, X Sun, Y Wang, L Li, F Yang… - Environmental …, 2024 - Elsevier
The prevalence of antibiotic resistance genes (ARGs) in the environment is a quintessential
One Health issue that threats both human and ecosystem health; however, the source and …

Distribution and genomic characterization of tigecycline-resistant tet(X4)-positive Escherichia coli of swine farm origin

Y Li, Q Wang, K Peng, Y Liu, X **ao… - Microbial …, 2021 - microbiologyresearch.org
The emergence of plasmid-mediated tigecycline-resistant strains is posing a serious threat
to food safety and human health, which has attracted worldwide attention. The tigecycline …

Source Tracking and Global Distribution of the Tigecycline Non-Susceptible tet(X)

R Zhang, J Sun, R Sun, M Wang, C Cui… - Microbiology …, 2021 - journals.asm.org
The emergence of tet (X) genes has compromised the clinical use of the last-line antibiotic
tigecycline. We identified 322 (1.21%) tet (X) positive samples from 12,829 human …

Structural diversity of the ISCR2-mediated rolling-cycle transferable unit carrying tet (X4)

D Liu, T Wang, D Shao, H Song, W Zhai, C Sun… - Science of The Total …, 2022 - Elsevier
Background Mobile tigecycline-resistance gene tet (X) variants have emerged as diverse
pathogens from animal, human as well as their associated environments, which could …