Complement system part I–molecular mechanisms of activation and regulation
NS Merle, SE Church, V Fremeaux-Bacchi… - Frontiers in …, 2015 - frontiersin.org
Complement is a complex innate immune surveillance system, playing a key role in defense
against pathogens and in host homeostasis. The complement system is initiated by …
against pathogens and in host homeostasis. The complement system is initiated by …
[HTML][HTML] A practical guide to small angle X-ray scattering (SAXS) of flexible and intrinsically disordered proteins
AG Kikhney, DI Svergun - FEBS letters, 2015 - Elsevier
Small-angle X-ray scattering (SAXS) is a biophysical method to study the overall shape and
structural transitions of biological macromolecules in solution. SAXS provides low resolution …
structural transitions of biological macromolecules in solution. SAXS provides low resolution …
Structural characterization of proteins and complexes using small-angle X-ray solution scattering
HDT Mertens, DI Svergun - Journal of structural biology, 2010 - Elsevier
Small-angle scattering of X-rays (SAXS) is an established method for the low-resolution
structural characterization of biological macromolecules in solution. The technique provides …
structural characterization of biological macromolecules in solution. The technique provides …
Structural basis for sialic acid–mediated self-recognition by complement factor H
The serum protein complement factor H (FH) ensures downregulation of the complement
alternative pathway, a branch of innate immunity, upon interaction with specific glycans on …
alternative pathway, a branch of innate immunity, upon interaction with specific glycans on …
Protection of host cells by complement regulators
The complement cascade is an ancient immune‐surveillance system that not only provides
protection from pathogen invasion but has also evolved to participate in physiological …
protection from pathogen invasion but has also evolved to participate in physiological …
Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering
P Bernado, DI Svergun - Molecular biosystems, 2012 - pubs.rsc.org
Small-angle scattering of X-rays (SAXS) is an established method to study the overall
structure and structural transitions of biological macromolecules in solution. For folded …
structure and structural transitions of biological macromolecules in solution. For folded …
Complement factor H in host defense and immune evasion
Complement is the major humoral component of the innate immune system. It recognizes
pathogen-and damage-associated molecular patterns, and initiates the immune response in …
pathogen-and damage-associated molecular patterns, and initiates the immune response in …
Hijacking factor H for complement immune evasion
The complement system is an essential player in innate and adaptive immunity. It consists of
three pathways (alternative, classical, and lectin) that initiate either spontaneously …
three pathways (alternative, classical, and lectin) that initiate either spontaneously …
Structural basis for engagement by complement factor H of C3b on a self surface
HP Morgan, CQ Schmidt, M Guariento… - Nature structural & …, 2011 - nature.com
Complement factor H (FH) attenuates C3b molecules tethered by their thioester domains to
self surfaces and thereby protects host tissues. Factor H is a cofactor for initial C3b …
self surfaces and thereby protects host tissues. Factor H is a cofactor for initial C3b …
Complement factor H in AMD: Bridging genetic associations and pathobiology
CB Toomey, LV Johnson, CB Rickman - Progress in retinal and eye …, 2018 - Elsevier
Abstract Age-Related Macular Degeneration (AMD) is a complex multifactorial disease
characterized in its early stages by lipoprotein accumulations in Bruch's Membrane (BrM) …
characterized in its early stages by lipoprotein accumulations in Bruch's Membrane (BrM) …