Signaling pathways in inflammation and anti-inflammatory therapies
YT Yeung, F Aziz, A Guerrero-Castilla… - Current …, 2018 - ingentaconnect.com
During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …
The role of p38 MAPK in the development of diabetic cardiomyopathy
S Wang, L Ding, H Ji, Z Xu, Q Liu, Y Zheng - International journal of …, 2016 - mdpi.com
Diabetic cardiomyopathy (DCM) is a major complication of diabetes that contributes to an
increase in mortality. A number of mechanisms potentially explain the development of DCM …
increase in mortality. A number of mechanisms potentially explain the development of DCM …
Long non-coding RNA MIAT regulates blood tumor barrier permeability by functioning as a competing endogenous RNA
J He, Y Xue, Q Wang, X Zhou, L Liu, T Zhang… - Cell Death & …, 2020 - nature.com
Blood–tumor barrier (BTB) presents a major obstacle to brain drug delivery. Therefore, it is
urgent to enhance BTB permeability for the treatment of glioma. In this study, we …
urgent to enhance BTB permeability for the treatment of glioma. In this study, we …
Oolong tea prevents cardiomyocyte loss against hypoxia by attenuating p‐JNK mediated hypertrophy and enhancing P‐IGF1R, p‐akt, and p‐Badser136 activity and …
MA Shibu, CH Kuo, BC Chen, DT Ju… - Environmental …, 2018 - Wiley Online Library
Tea, the most widely consumed natural beverage has been associated with reduced
mortality risk from cardiovascular disease. Oolong tea is a partially fermented tea containing …
mortality risk from cardiovascular disease. Oolong tea is a partially fermented tea containing …
Leech extract: a candidate cardioprotective against hypertension-induced cardiac hypertrophy and fibrosis
Ethnopharmacological relevance The prevalence of cardiovascular diseases (CVDs) has
been increasing worldwide. Despite significant improvements in therapeutics and on-going …
been increasing worldwide. Despite significant improvements in therapeutics and on-going …
Fisetin activates Hippo pathway and JNK/ERK/AP‐1 signaling to inhibit proliferation and induce apoptosis of human osteosarcoma cells via ZAK overexpression
CY Fu, MC Chen, YS Tseng, MC Chen… - Environmental …, 2019 - Wiley Online Library
Osteosarcoma (OS) is a tumor entity that can cause a large number of cancer‐related
deaths. Although chemotherapy can decrease proliferation and increase apoptosis of …
deaths. Although chemotherapy can decrease proliferation and increase apoptosis of …
Cellular apoptosis and cardiac dysfunction in STZ‐induced diabetic rats attenuated by anthocyanins via activation of IGFI‐R/PI3K/Akt survival signaling
PC Huang, GJ Wang, MJ Fan… - Environmental …, 2017 - Wiley Online Library
Anthocyanins are known cyto‐protective agents against various stress conditions. In this
study cardio‐protective effect of anthocyanins from black rice against diabetic mellitus (DM) …
study cardio‐protective effect of anthocyanins from black rice against diabetic mellitus (DM) …
Recessive mutations in the kinase ZAK cause a congenital myopathy with fibre type disproportion
Congenital myopathies define a heterogeneous group of neuromuscular diseases with
neonatal or childhood hypotonia and muscle weakness. The genetic cause is still unknown …
neonatal or childhood hypotonia and muscle weakness. The genetic cause is still unknown …
SUMO proteins in the cardiovascular system: friend or foe?
PMV Shetty, AY Rangrez, N Frey - Journal of Biomedical Science, 2020 - Springer
Post-translational modifications (PTMs) are crucial for the adaptation of various signalling
pathways to ensure cellular homeostasis and proper adaptation to stress. PTM is a covalent …
pathways to ensure cellular homeostasis and proper adaptation to stress. PTM is a covalent …
Targeted inhibition of ZAK ameliorates renal interstitial fibrosis
S Shu, H Liu, J Yang, H Tang, H Li, Z Liu, M Zhou… - Translational …, 2022 - Elsevier
ZAK (sterile alpha motif and leucine zipper-containing kinase) is a newly discovered
member of the subfamily of mitogen-activated protein kinase kinase kinases (MAP3Ks). The …
member of the subfamily of mitogen-activated protein kinase kinase kinases (MAP3Ks). The …