Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Inflammatory Arthritis is characterized by synovial proliferation, neovascularization and
leukocyte extravasation leading to joint destruction and functional disability. Efficiency of …

The highly conserved Notch signalling pathway functions in many different developmental
and homeostatic processes, which raises the question of how this pathway can achieve …

Cellular energy is primarily provided by the oxidative degradation of nutrients coupled with
mitochondrial respiration, in which oxygen participates in the mitochondrial electron …

The cellular response to oxygen deprivation is governed largely by a family of transcription
factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular …

The epithelial-mesenchymal transition (EMT) is an essential mechanism in embryonic
development and tissue repair. EMT also contributes to the progression of disease …

Iron-dependent lipid peroxidation causes ferroptosis, a form of regulated cell death. Crucial
steps in the formation of ferroptosis include the accumulation of ferrous ions (Fe2+) and lipid …

Synovial proliferation, neovascularization and leukocyte extravasation transform the
normally acellular synovium into an invasive tumour-like'pannus'. The highly dysregulated …

Notch pathway is an evolutionarily conserved signalling system that operates to influence an
astonishing array of cell fate decisions in different developmental contexts. Notch signalling …

The Notch signalling pathway is evolutionarily conserved and is crucial for the development
and homeostasis of most tissues. Deregulated Notch signalling leads to various diseases …