The mammalian striatin family consists of three proteins, striatin, S/G 2 nuclear autoantigen,
and zinedin. Striatin family members have no intrinsic catalytic activity, but rather function as …

Cerebral cavernous malformations (CCM) are manifested by microvascular lesions
characterized by leaky endothelial cells with minimal intervening parenchyma …

The Hippo pathway regulates organ size and tissue homeostasis in response to multiple
stimuli, including cell density and mechanotransduction. Pharmacological inhibition of …

Schistosome parasites kill 250,000 people every year. Treatment of schistosomiasis relies
on the drug praziquantel. Unfortunately, a scarcity of molecular tools has hindered the …

Purpose: The phenotypic manifestations of cerebral cavernous malformation disease
caused by rare PDCD10 mutations have not been systematically examined, and a …

X-chromosome inactivation (XCI) provides a dosage compensation mechanism where, in
each female cell, one of the two X chromosomes is randomly silenced. However, some …

Cerebral cavernous malformations (CCMs) are alterations in brain capillary architecture that
can result in neurological deficits, seizures, or stroke. We recently demonstrated that CCM3 …

The mechanisms governing apical membrane assembly during biological tube development
are poorly understood. Here, we show that extension of the C. elegans excretory canal …

Immune responses need to be tightly controlled to avoid excessive inflammation and
prevent unwanted host damage. Here we report that germinal center kinase MST4 …

CCM 3, a product of the cerebral cavernous malformation 3 or programmed cell death 10
gene (CCM 3/PDCD 10), is broadly expressed throughout development in both vertebrates …