The vast majority of the brain's vascular length is composed of capillaries, where our
understanding of blood flow control remains incomplete. This review synthesizes current …

Many central nervous system diseases currently lack effective treatment and are often
associated with defects in microvascular function, including a failure to match the energy …

Recent evidence suggests that capillary pericytes are contractile and play a crucial role in
the regulation of microcirculation. However, failure to detect components of the contractile …

Retinal ganglion cells, the neurons that die in glaucoma, are endowed with a high
metabolism requiring optimal provision of oxygen and nutrients to sustain their activity. The …

After cardiac ischaemia, a prolonged decrease of coronary microvascular perfusion often
occurs even after flow is restored in an upstream artery. This' no-reflow'phenomenon …

Ever since the introduction of thrombolysis and the subsequent expansion of endovascular
treatments for acute ischemic stroke, it remains to be identified why the actual outcomes are …

Highlights•Astrocytes regulate brain energy supply at several loci.•Astrocytes adjust blood
flow at the capillary level via pericytes.•Controversy persists over lactate transfer between …

Objective Blood–brain barrier (BBB) impairment, redistribution of pericytes, and
disturbances in cerebral blood flow may contribute to the increased seizure propensity and …

Adenosine is an inhibitory modulator of neuronal excitability. Neuronal activity results in
increased adenosine release, thereby constraining excessive excitation. The exceptionally …

Depression is a highly prevalent psychological disorder characterized by persistent
dysphoria, psychomotor retardation, insomnia, anhedonia, suicidal ideation, and a …