Ageing is the main risk factor for the development of cardiovascular diseases. A central
mechanism by which ageing promotes vascular pathologies is compromising endothelial …

Pericytes are unique, multi-functional mural cells localized at the abluminal side of the
perivascular space in microvessels. Originally discovered in 19th century, pericytes had …

Tumours can obtain nutrients and oxygen required to progress and metastasize through the
blood supply. Inducing angiogenesis involves the sprouting of established vessel beds and …

Physical exercise can improve brain function and delay neurodegeneration; however, the
initial signal from muscle to brain is unknown. Here we show that the lactate receptor …

Multilayered skin substitutes comprising allogeneic cells have been tested for the treatment
of nonhealing cutaneous ulcers. However, such nonnative skin grafts fail to permanently …

Recently, phage display technology has been announced as the recipient of Nobel Prize in
Chemistry 2018. Phage display technique allows high affinity target-binding peptides to be …

Many central nervous system diseases currently lack effective treatment and are often
associated with defects in microvascular function, including a failure to match the energy …

Vascular smooth muscle cells (SMCs), a major structural component of the vessel wall, not
only play a key role in maintaining vascular structure but also perform various functions …

Stroke is the leading cause of disability and mortality in the world, but the pathogenesis of
ischemic stroke (IS) is not completely clear and treatments are limited. Mounting evidence …

Direct contact and communication between pericytes and endothelial cells is critical for
maintenance of cerebrovascular stability and blood-brain barrier function. Capillary …