Developmental mechanisms underlying the evolution of human cortical circuits

P Vanderhaeghen, F Polleux - Nature Reviews Neuroscience, 2023 - nature.com
The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …

The musical abilities, pleiotropy, language, and environment (MAPLE) framework for understanding musicality-language links across the lifespan

S Nayak, PL Coleman, E Ladányi, R Nitin… - Neurobiology of …, 2022 - direct.mit.edu
Using individual differences approaches, a growing body of literature finds positive
associations between musicality and language-related abilities, complementing prior …

Discovery of 42 genome-wide significant loci associated with dyslexia

C Doust, P Fontanillas, E Eising, SD Gordon, Z Wang… - Nature …, 2022 - nature.com
Reading and writing are crucial life skills but roughly one in ten children are affected by
dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up …

Genome-wide analyses of individual differences in quantitatively assessed reading-and language-related skills in up to 34,000 people

E Eising, N Mirza-Schreiber… - Proceedings of the …, 2022 - National Acad Sciences
The use of spoken and written language is a fundamental human capacity. Individual
differences in reading-and language-related skills are influenced by genetic variation, with …

The genetic relationships between brain structure and schizophrenia

EM Stauffer, RAI Bethlehem, L Dorfschmidt… - Nature …, 2023 - nature.com
Genetic risks for schizophrenia are theoretically mediated by genetic effects on brain
structure but it has been unclear which genes are associated with both schizophrenia and …

Using neuroimaging genomics to investigate the evolution of human brain structure

G Alagöz, B Molz, E Eising… - Proceedings of the …, 2022 - National Acad Sciences
Alterations in brain size and organization represent some of the most distinctive changes in
the emergence of our species. Yet, there is limited understanding of how genetic factors …

Neuroimaging genomics as a window into the evolution of human sulcal organization

O Goltermann, G Alagöz, B Molz, SE Fisher - Cerebral Cortex, 2024 - academic.oup.com
Primate brain evolution has involved prominent expansions of the cerebral cortex, with
largest effects observed in the human lineage. Such expansions were accompanied by fine …

Temporal map** of derived high-frequency gene variants supports the mosaic nature of the evolution of Homo sapiens

A Andirkó, J Moriano, A Vitriolo, M Kuhlwilm, G Testa… - Scientific Reports, 2022 - nature.com
Large-scale estimations of the time of emergence of variants are essential to examine
hypotheses concerning human evolution with precision. Using an open repository of genetic …

A molecular and cellular perspective on human brain evolution and tempo

FW Lindhout, FM Krienen, KS Pollard, MA Lancaster - Nature, 2024 - nature.com
The evolution of the modern human brain was accompanied by distinct molecular and
cellular specializations, which underpin our diverse cognitive abilities but also increase our …

Insights into the genetic architecture of cerebellar lobules derived from the UK Biobank

A Carrión-Castillo, C Boeckx - Scientific Reports, 2024 - nature.com
In this work we endeavor to further understand the genetic architecture of the cerebellum by
examining the genetic underpinnings of the different cerebellar lob (ul) es, identifying their …