Targeting angiogenesis in oncology, ophthalmology and beyond

Y Cao, R Langer, N Ferrara - Nature Reviews Drug Discovery, 2023 - nature.com
Angiogenesis is an essential process in normal development and in adult physiology, but
can be disrupted in numerous diseases. The concept of targeting angiogenesis for treating …

Scientific, sustainability and regulatory challenges of cultured meat

MJ Post, S Levenberg, DL Kaplan, N Genovese, J Fu… - Nature Food, 2020 - nature.com
Cellular agriculture is an emerging branch of biotechnology that aims to address issues
associated with the environmental impact, animal welfare and sustainability challenges of …

Obese visceral fat tissue inflammation: from protective to detrimental?

H Kolb - BMC medicine, 2022 - Springer
Obesity usually is accompanied by inflammation of fat tissue, with a prominent role of
visceral fat. Chronic inflammation in obese fat tissue is of a lower grade than acute immune …

Adipose tissue fibrosis in obesity: etiology and challenges

G Marcelin, EL Gautier, K Clément - Annual review of physiology, 2022 - annualreviews.org
Obesity is a chronic and progressive process affecting whole-body energy balance and is
associated with comorbidity development. In addition to increased fat mass, obesity induces …

Adipose tissue remodeling in pathophysiology

C Auger, S Kajimura - Annual Review of Pathology: Mechanisms …, 2023 - annualreviews.org
Rather than serving as a mere onlooker, adipose tissue is a complex endocrine organ and
active participant in disease initiation and progression. Disruptions of biological processes …

[HTML][HTML] Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk

JH Stern, JM Rutkowski, PE Scherer - Cell metabolism, 2016 - cell.com
Metabolism research has made tremendous progress over the last several decades in
establishing the adipocyte as a central rheostat in the regulation of systemic nutrient and …

Deciphering the cellular interplays underlying obesity-induced adipose tissue fibrosis

G Marcelin, ALM Silveira, LB Martins… - The Journal of …, 2019 - Am Soc Clin Investig
Obesity originates from an imbalance between caloric intake and energy expenditure that
promotes adipose tissue expansion, which is necessary to buffer nutrient excess. Patients …

Endothelial permeability, LDL deposition, and cardiovascular risk factors—A review

S Mundi, M Massaro, E Scoditti… - Cardiovascular …, 2018 - academic.oup.com
Early atherosclerosis features functional and structural changes in the endothelial barrier
function that affect the traffic of molecules and solutes between the vessel lumen and the …

Angiogenesis in adipose tissue: the interplay between adipose and endothelial cells

J Herold, J Kalucka - Frontiers in physiology, 2021 - frontiersin.org
Obesity is a worldwide health problem, and as its prevalence increases, so does the burden
of obesity-associated co-morbidities like type 2 diabetes or cardiovascular diseases (CVDs) …

Tissue engineering for clean meat production

T Ben-Arye, S Levenberg - Frontiers in Sustainable Food Systems, 2019 - frontiersin.org
Increasing public awareness of foodborne illnesses, factory farming, and the ecological
footprint of the meat industry, has generated the need for animal-free meat alternatives. In …