Arynes are among the most active organic intermediates and have found numerous
applications in expeditious preparation of substituted arenes. In the past 20 years, chemists …

Tetrahydroquinoline is one of the most important simple nitrogen heterocycles, being
widespread in nature and present in a broad variety of pharmacologically active …

Melatonin receptors are seven transmembrane‐spanning proteins belonging to the GPCR
superfamily. In mammals, two melatonin receptor subtypes exist‐MT1 and MT2‐encoded by …

Melatonin, N‐acetyl‐5‐methoxytryptamine, an evolutionally old molecule, is produced by the
pineal gland in vertebrates, and it binds with high affinity to melatonin receptors, which are …

Abstract Melatonin (5‐methoxy‐N‐acetyltryptamine) binds with high affinity and specificity to
membrane receptors. Several receptor subtypes exist in different species, of which the …

The human MT1 and MT2 melatonin receptors, are G-protein-coupled receptors (GPCRs)
that help to regulate circadian rhythm and sleep patterns. Drug development efforts have …

The H2O-promoted controllable synthesis of diverse nitrogen heterocycles from readily
available feedstocks was developed by a hydride transfer strategy. A variety of 3-carboxyl …

Melatonin (MLT) exerts its physiological effects principally through two high‐affinity
membrane receptors MT1 and MT2. Understanding the exact mechanism of MLT action …

Accumulated pieces of evidence have proved the beneficial effects of melatonin on
myocardial ischemia/reperfusion (MI/R) injury, and these effects were largely dependent on …