Molecular insights into regulatory RNAs in the cellular machinery

S Yang, SH Kim, E Yang, M Kang, JY Joo - Experimental & Molecular …, 2024‏ - nature.com
It is apparent that various functional units within the cellular machinery are derived from
RNAs. The evolution of sequencing techniques has resulted in significant insights into …

Harnessing deep learning into hidden mutations of neurological disorders for therapeutic challenges

S Yang, SH Kim, M Kang, JY Joo - Archives of Pharmacal Research, 2023‏ - Springer
The relevant study of transcriptome-wide variations and neurological disorders in the
evolved field of genomic data science is on the rise. Deep learning has been highlighted …

PLC-CN-NFAT1 signaling-mediated Aβ and IL-1β crosstalk synergistically promotes hippocampal neuronal damage

Q Shi, X Sun, H Zhang, L Yang, Y Fu, G Wang… - International …, 2024‏ - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease. Neuronal calcium
overload plays an important role in Aβ deposition and neuroinflammation, which are strongly …

PLC regulates spontaneous glutamate release triggered by extracellular calcium and readily releasable pool size in neocortical neurons

MG Feldthouse, NP Vyleta, SM Smith - Frontiers in Cellular …, 2023‏ - frontiersin.org
Introduction Dynamic physiological changes in brain extracellular calcium ([Ca2+] o) occur
when high levels of neuronal activity lead to substantial Ca2+ entry via ion channels …

Engineering and Application of Optogenetic Tools to Interrogate GPCR-G Protein Signaling

S Ubeysinghe - 2024‏ - search.proquest.com
GPCRs play a vital role in regulating a wide variety of physiological processes, including
neurotransmission, immune responses, cell migration, and hormonal regulation, and are …