Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s),
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …

Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

Duchenne muscular dystrophy (DMD) is a severe, progressive, and ultimately fatal disease
of skeletal muscle wasting, respiratory insufficiency, and cardiomyopathy. The identification …

Dystrophin is the central protein of the dystrophin-glycoprotein complex (DGC) in skeletal
and heart muscle cells. Dystrophin connects the actin cytoskeleton to the extracellular matrix …

Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy, and despite
advances in genetic and pharmacological disease-modifying treatments, its management …

Sarcopenia characterized by reduced skeletal muscle mass and decreased muscle strength
is increasing in prevalence globally. The pathophysiology of sarcopenia is related to various …

Mitochondrial stress may be a secondary contributor to muscle weakness in inherited
muscular dystrophies. Duchenne muscular dystrophy has received the majority of attention …

Calcium (Ca2+) ions act as a second messenger, regulating several cell functions.
Mitochondria are critical organelles for the regulation of intracellular Ca2+. Mitochondrial …

Background Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD)
are characterized by muscle wasting leading to loss of ambulation in the first or third decade …

Duchenne muscular dystrophy (DMD) is caused by the absence of the dystrophin protein
and a properly functioning dystrophin-associated protein complex (DAPC) in muscle cells …