Role of animal models in biomedical research: a review

P Mukherjee, S Roy, D Ghosh, SK Nandi - Laboratory Animal Research, 2022 - Springer
The animal model deals with the species other than the human, as it can imitate the disease
progression, its' diagnosis as well as a treatment similar to human. Discovery of a drug …

Immunomodulatory biomaterials for implant-associated infections: from conventional to advanced therapeutic strategies

J Dong, W Wang, W Zhou, S Zhang, M Li, N Li… - Biomaterials …, 2022 - spj.science.org
Implant-associated infection (IAI) is increasingly emerging as a serious threat with the
massive application of biomaterials. Bacteria attached to the surface of implants are often …

Synergistic effects of dual Zn/Ag ion implantation in osteogenic activity and antibacterial ability of titanium

G **, H Qin, H Cao, S Qian, Y Zhao, X Peng, X Zhang… - Biomaterials, 2014 - Elsevier
Abstract Zinc (Zn) and silver (Ag) are co-implanted into titanium by plasma immersion ion
implantation. A Zn containing film with Ag nanoparticles (Ag NPs) possessing a wide size …

Chronic implant-related bone infections—can immune modulation be a therapeutic strategy?

E Seebach, KF Kubatzky - Frontiers in immunology, 2019 - frontiersin.org
Chronic implant-related bone infections are a major problem in orthopedic and trauma-
related surgery with severe consequences for the affected patients. As antibiotic resistance …

Antibacterial and immunogenic behavior of silver coatings on additively manufactured porous titanium

M Croes, S Bakhshandeh, IAJ Van Hengel, K Lietaert… - Acta biomaterialia, 2018 - Elsevier
Implant-associated infections (IAI) are often recurrent, expensive to treat, and associated
with high rates of morbidity, if not mortality. We biofunctionalized the surface of additively …

In vitro and in vivo anti-biofilm effects of silver nanoparticles immobilized on titanium

H Qin, H Cao, Y Zhao, C Zhu, T Cheng, Q Wang… - Biomaterials, 2014 - Elsevier
Prevention of periprosthetic infection (PPI) by inhibiting biofilm formation on prostheses is
crucial to orthopedic surgery. In this work, silver nanoparticles (Ag NPs) are fabricated in situ …

Gentamicin coating of metallic implants reduces implant-related osteomyelitis in rats

M Lucke, G Schmidmaier, S Sadoni, B Wildemann… - Bone, 2003 - Elsevier
Antibiotic prophylaxis is a routine procedure in orthopedic surgery. Various local antibiotic
delivery techniques are used to reduce bone-and soft tissue-related infection. The objective …

Prophylaxis and treatment of implant-related infections by antibiotic-coated implants: a review

G Schmidmaier, M Lucke, B Wildemann, NP Haas… - Injury, 2006 - Elsevier
Implant-related infection is a feared complication in orthopedic and trauma surgery with
tremendous consequences for the patient. To reduce this risk, administration of …

The use of gentamicin-coated nails in the tibia: preliminary results of a prospective study

T Fuchs, R Stange, G Schmidmaier… - Archives of orthopaedic …, 2011 - Springer
Background The use of antibiotic-coated implants may reduce the rate of infection and
facilitate fracture healing after surgical treatment of tibial shaft fractures. A new …

[HTML][HTML] Layer by layer coating for bio-functionalization of additively manufactured meta-biomaterials

SA Yavari, M Croes, B Akhavan, F Jahanmard… - Additive …, 2020 - Elsevier
Additive manufacturing has facilitated fabrication of complex and patient-specific metallic
meta-biomaterials that offer an unprecedented collection of mechanical, mass transport, and …