Despite advances in neurosurgery, chemotherapy and radiotherapy, glioblastoma remains
one of the most treatment-resistant CNS malignancies, and the tumour inevitably recurs. The …

Naturally occurring stem cells isolated from humans have been used therapeutically for
decades. This has primarily involved the transplantation of primary cells such as …

Background Malignant glioma is the most common and lethal primary brain tumour, with
dismal survival rates and no effective treatment. We examined the safety and activity of NSC …

Clinical investigations using stem cell products in regenerative medicine are addressing a
wide spectrum of conditions using a variety of stem cell types. To date, there have been few …

Autologous T cells that have been genetically modified to express a chimeric antigen
receptor (CAR) targeting the B cell antigen CD19 have yielded remarkable clinical …

One of the landmark events of the past 25 years in neuroscience research was the
establishment of neural stem cells (NSCs) as a life-long source of neurons and glia, a …

Nanocarriers (NCs) play a crucial role in delivering theranostic agents to tumors, making
them a pivotal focus of research. However, the persistently low delivery efficiency of …

Metastatic cancer cells generally cannot be eradicated using traditional surgical or
chemoradiotherapeutic strategies, and disease recurrence is extremely common following …

The intricate pathophysiology of brain disorders, difficult access to the brain, and the
complexity and high risks and costs of drug development represent major hurdles for …

How to improve effective accumulation and intratumoral distribution of plasmonic gold
nanoparticles has become a great challenge for photothermal therapy of tumors. Herein, we …