Tumour-associated macrophages (TAMs) are crucial components of the tumour
microenvironment and play a significant role in tumour development and drug resistance by …

Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …

Hypodermis is the predominant site of Staphylococcus aureus infections that cause cellulitis.
Given the importance of macrophages in tissue remodeling, we examined the hypodermal …

Osteoarthritis is a disease that impacts millions around the world, leading to significant
financial and medical burden for patients and the healthcare system. However, no effective …

Bone marrow fibrosis represents an important structural change in the marrow that interferes
with some of its normal functions. The aetiopathogenesis of fibrosis is not well established …

Background Macrophages play a dual role in neuroinflammatory disorders such as multiple
sclerosis (MS). They are involved in lesion onset and progression but can also promote the …

Background Signal transducer and activator of transcription 3 (STAT3), a multifaceted
transcription factor, modulates host immune responses by activating cellular response to …

Macrophages, as one of the most abundant tumor-infiltrating cells, play an important role in
tumor development and metastasis. The frequency and polarization of tumor-associated …

Fungi are abundant in the environment, causing our lungs to be constantly exposed to a
diverse range of species. While the majority of these are cleared effectively in healthy …

Viruses are obligate intracellular parasites that rely on host cell metabolism for successful
replication. Thus, viruses rewire host cell pathways involved in central carbon metabolism to …