Asthma is a chronic inflammatory airway disease resulting in airflow obstruction, which in
part can become irreversible to conventional therapies, defining the concept of airway …

The community of cells lining our airways plays a collaborative role in the preservation of
immune homeostasis in the lung and provides protection from the pathogens and pollutants …

T lymphocytes, the major effector cells in cellular immunity, produce cytokines in immune
responses to mediate inflammation and regulate other types of immune cells. Work in the …

Asthma is a chronic inflammatory airway disease associated with type 2 cytokines
interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus …

Asthma is a chronic disease of the airways, which affects more than 350 million people
worldwide. It is the most common chronic disease in children, affecting at least 30 million …

The human lung plays vital roles in respiration, host defense, and basic physiology. Recent
technological advancements such as single-cell RNA sequencing and genetic lineage …

Immune cells undergo rapid and extensive metabolic changes during inflammation. In
addition to contributing to energetic and biosynthetic demands, metabolites can also …

Pathogens and inflammatory conditions rapidly induce the expression of immune-
responsive gene 1 (IRG1) in cells of myeloid lineage. IRG1 encodes an aconitate …

Tuft cells are rare, secretory epithelial cells that generated scant immunological interest until
contemporaneous reports in 2016 linked tuft cells with type 2 immunity in the small intestine …

Because of the stochasticity associated with high-throughput single-cell sequencing, current
methods for exploring cell-type diversity rely on clustering-based computational approaches …