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[HTML][HTML] Biomarkers in cancer detection, diagnosis, and prognosis
Biomarkers are vital in healthcare as they provide valuable insights into disease diagnosis,
prognosis, treatment response, and personalized medicine. They serve as objective …
prognosis, treatment response, and personalized medicine. They serve as objective …
The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to develo** treatment
Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …
Nasopharyngeal carcinoma: current views on the tumor microenvironment's impact on drug resistance and clinical outcomes
The incidence of nasopharyngeal carcinoma (NPC) exhibits significant variations across
different ethnic groups and geographical regions, with Southeast Asia and North Africa …
different ethnic groups and geographical regions, with Southeast Asia and North Africa …
Single-cell transcriptional diversity is a hallmark of developmental potential
Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular
differentiation trajectories. However, inferring both the state and direction of differentiation is …
differentiation trajectories. However, inferring both the state and direction of differentiation is …
Lipid droplets: platforms with multiple functions in cancer hallmarks
Lipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play
important roles in cell signaling, lipid metabolism, membrane trafficking, and the production …
important roles in cell signaling, lipid metabolism, membrane trafficking, and the production …
EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
The success of anticancer therapy is usually limited by the development of drug resistance.
Such acquired resistance is driven, in part, by intratumoural heterogeneity—that is, the …
Such acquired resistance is driven, in part, by intratumoural heterogeneity—that is, the …
Hypoxia-modified cancer cell metabolism
While oxygen is critical to the continued existence of complex organisms, extreme levels of
oxygen within a system, known as hypoxia (low levels of oxygen) and hyperoxia (excessive …
oxygen within a system, known as hypoxia (low levels of oxygen) and hyperoxia (excessive …
A highlight on Sonic hedgehog pathway
GB Carballo, JR Honorato, GPF de Lopes… - Cell Communication and …, 2018 - Springer
Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic
development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is …
development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is …
Cancer stem cell mimicry for immune evasion and therapeutic resistance
Cancer stem cells (CSCs) are heterogeneous, possess self-renewal attributes, and
orchestrate important crosstalk in tumors. We propose that the CSC state represents" …
orchestrate important crosstalk in tumors. We propose that the CSC state represents" …
[HTML][HTML] Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion, and recurrence following chemotherapy
We test the hypothesis that glioblastoma harbors quiescent cancer stem cells that evade anti-
proliferative therapies. Functional characterization of spontaneous glioblastomas from …
proliferative therapies. Functional characterization of spontaneous glioblastomas from …