[HTML][HTML] Aging and age‐related diseases: from mechanisms to therapeutic strategies
Z Li, Z Zhang, Y Ren, Y Wang, J Fang, H Yue, S Ma… - Biogerontology, 2021 - Springer
Aging is a physiological process mediated by numerous biological and genetic pathways,
which are directly linked to lifespan and are a driving force for all age-related diseases …
which are directly linked to lifespan and are a driving force for all age-related diseases …
Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia
S Peixoto da Silva, JMO Santos… - Journal of cachexia …, 2020 - Wiley Online Library
Cancer cachexia is a multifactorial syndrome characterized by a progressive loss of skeletal
muscle mass, along with adipose tissue wasting, systemic inflammation and other metabolic …
muscle mass, along with adipose tissue wasting, systemic inflammation and other metabolic …
Blocking PD-L1–PD-1 improves senescence surveillance and ageing phenotypes
The accumulation of senescent cells is a major cause of age-related inflammation and
predisposes to a variety of age-related diseases. However, little is known about the …
predisposes to a variety of age-related diseases. However, little is known about the …
Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength
INTRODUCTION Currently there are no approved treatments for sarcopenia, the age-
dependent loss of skeletal muscle mass and strength that constitutes a major public health …
dependent loss of skeletal muscle mass and strength that constitutes a major public health …
Age-related changes in skeletal muscle: changes to life-style as a therapy
R McCormick, A Vasilaki - Biogerontology, 2018 - Springer
As we age, there is an age-related loss in skeletal muscle mass and strength, known as
sarcopenia. Sarcopenia results in a decrease in mobility and independence, as well as an …
sarcopenia. Sarcopenia results in a decrease in mobility and independence, as well as an …
[HTML][HTML] Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells
S Fulzele, B Mendhe, A Khayrullin, M Johnson… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs) are known to play important roles in cell-cell communication.
Here we investigated the role of muscle-derived EVs and their microRNAs in the loss of …
Here we investigated the role of muscle-derived EVs and their microRNAs in the loss of …
Lesion level–dependent systemic muscle wasting after spinal cord injury is mediated by glucocorticoid signaling in mice
An incomplete mechanistic understanding of skeletal muscle wasting early after spinal cord
injury (SCI) precludes targeted molecular interventions. Here, we demonstrated systemic …
injury (SCI) precludes targeted molecular interventions. Here, we demonstrated systemic …
Regeneration of neuromuscular synapses after acute and chronic denervation by inhibiting the gerozyme 15-prostaglandin dehydrogenase
To date, there are no approved treatments for the diminished strength and paralysis that
result from the loss of peripheral nerve function due to trauma, heritable neuromuscular …
result from the loss of peripheral nerve function due to trauma, heritable neuromuscular …
[HTML][HTML] Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration
In aging, skeletal muscle strength and regenerative capacity decline, due in part to
functional impairment of muscle stem cells (MuSCs), yet the underlying mechanisms remain …
functional impairment of muscle stem cells (MuSCs), yet the underlying mechanisms remain …
Cognitive reserve in model systems for mechanistic discovery: The importance of longitudinal studies
The goal of this review article is to provide a resource for longitudinal studies, using animal
models, directed at understanding and modifying the relationship between cognition and …
models, directed at understanding and modifying the relationship between cognition and …