Muscles and bones are intricately connected tissues displaying marked co-variation during
development, growth, aging, and in many diseases. While the diagnosis and treatment of …

A sedentary lifestyle is associated with overweight/obesity, which involves excessive fat
body accumulation, triggering structural and functional changes in tissues, organs, and body …

Receptor activator of NF-κB ligand (RANKL) activates, while osteoprotegerin (OPG) inhibits,
osteoclastogenesis. A neutralizing Ab against RANKL, denosumab, improves bone strength …

Among the physiological consequences of extended spaceflight are loss of skeletal muscle
and bone mass. One signaling pathway that plays an important role in maintaining muscle …

Although their physiology and functions are very different, bones, skeletal and smooth
muscles, as well as the heart have the same embryonic origin. Skeletal muscles and bones …

Abstract Purpose of Review In this review we aim to summarize the latest findings on the
network of molecules produced by muscle and bone under physiological and pathological …

Bisphosphonates prevent bone loss in glucocorticoid (GC)-treated boys with Duchenne
muscular dystrophy (DMD) and are recommended as standard of care. Targeting receptor …

The dissociation of bone formation and resorption is an important physiological process
during spaceflight. It also occurs during local skeletal unloading or immobilization, such as …

Duchenne muscular dystrophy (DMD) is the most severe form of muscular dystrophy which
leads to progressive muscle degeneration and inflammation. The receptor activator of …

Skeletal muscle dysfunction is one of the important comorbidities of chronic obstructive
pulmonary disease (COPD); however, the underlying mechanisms remain largely unknown …