Antimicrobial resistance: a concise update

CS Ho, CTH Wong, TT Aung… - The Lancet …, 2024 - thelancet.com
Antimicrobial resistance (AMR) is a serious threat to global public health, with approximately
5 million deaths associated with bacterial AMR in 2019. Tackling AMR requires a …

[HTML][HTML] A comprehensive review on phage therapy and phage-based drug development

L Cui, S Watanabe, K Miyanaga, K Kiga, T Sasahara… - Antibiotics, 2024 - mdpi.com
Phage therapy, the use of bacteriophages (phages) to treat bacterial infections, is regaining
momentum as a promising weapon against the rising threat of multidrug-resistant (MDR) …

Towards Standardization of Phage Susceptibility Testing: The Israeli Phage Therapy Center “Clinical Phage Microbiology”—A Pipeline Proposal

O Yerushalmy, R Braunstein… - Clinical Infectious …, 2023 - academic.oup.com
Using phages as salvage therapy for nonhealing infections is gaining recognition as a
viable solution for patients with such infections. The escalating issue of antibiotic resistance …

Current status of bacteriophage therapy for severe bacterial infections

T Sawa, K Moriyama, M Kinoshita - Journal of Intensive Care, 2024 - Springer
The increase in the incidence of antibiotic-resistant bacteria poses a global public health
threat. According to a 2019 WHO report, approximately 1.27 million deaths were attributed to …

A Klebsiella-phage cocktail to broaden the host range and delay bacteriophage resistance both in vitro and in vivo

H Chen, H Liu, Y Gong, RA Dunstan, Z Ma… - npj Biofilms and …, 2024 - nature.com
Bacteriophages (phages), viruses capable of infecting and lysing bacteria, are a promising
alternative for treating infections from hypervirulent, antibiotic-resistant pathogens like …

The Safety and Efficacy of Phage Therapy for Infections in Cardiac and Peripheral Vascular Surgery: A Systematic Review

EA Simpson, CS MacLeod, HJ Stacey, J Nagy… - Antibiotics, 2023 - mdpi.com
New approaches to managing infections in cardiac and peripheral vascular surgery are
required to reduce costs to patients and healthcare providers. Bacteriophage (phage) …

[HTML][HTML] Phages and phage-borne enzymes as new antibacterial agents

S McCallin, Z Drulis-Kawa, T Ferry, JP Pirnay… - Clinical Microbiology …, 2023 - Elsevier
Background Persistent and resistant infections caused by bacteria are increasing in
numbers and pose a treatment challenge to the medical community and public health …

Improving phage therapy by evasion of phage resistance mechanisms

I Bleriot, O Pacios, L Blasco… - JAC-Antimicrobial …, 2024 - academic.oup.com
Antibiotic failure is one of the most worrisome threats to global health. Among the new
therapeutic efforts that are being explored, the use of bacteriophages (viruses that kill …

Phage susceptibility testing methods or 'phagograms': where do we stand and where should we go?

C Kolenda, J Jourdan… - Journal of …, 2024 - academic.oup.com
Phage therapy is a highly promising approach to address the challenge that is presented by
the global burden of antimicrobial resistance. Given the natural specificity of phages, phage …

Automating Predictive Phage Therapy Pharmacology

ST Abedon - Antibiotics, 2023 - mdpi.com
Viruses that infect as well as often kill bacteria are called bacteriophages, or phages.
Because of their ability to act bactericidally, phages increasingly are being employed …