Tau and neuroinflammation in Alzheimer's disease: interplay mechanisms and clinical translation

Y Chen, Y Yu - Journal of neuroinflammation, 2023‏ - Springer
Alzheimer's Disease (AD) contributes to most cases of dementia. Its prominent
neuropathological features are the extracellular neuritic plaques and intercellular …

The amyloid cascade hypothesis: an updated critical review

KP Kepp, NK Robakis, PF Høilund-Carlsen, SL Sensi… - Brain, 2023‏ - academic.oup.com
Results from recent clinical trials of antibodies that target amyloid-β (Aβ) for Alzheimer's
disease have created excitement and have been heralded as corroboration of the amyloid …

Peripheral and central immune system crosstalk in Alzheimer disease—a research prospectus

BM Bettcher, MG Tansey, G Dorothée… - Nature Reviews …, 2021‏ - nature.com
Dysregulation of the immune system is a cardinal feature of Alzheimer disease (AD), and a
considerable body of evidence indicates pathological alterations in central and peripheral …

Memantine for the treatment of dementia: a review on its current and future applications

J Folch, O Busquets, M Ettcheto… - Journal of …, 2018‏ - journals.sagepub.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the presence in
the brain of extracellular amyloid-β protein (Aβ) and intracellular neurofibrillary tangles …

Plasma lipidome is dysregulated in Alzheimer's disease and is associated with disease risk genes

Y Liu, A Thalamuthu, KA Mather, J Crawford… - Translational …, 2021‏ - nature.com
Lipidomics research could provide insights of pathobiological mechanisms in Alzheimer's
disease. This study explores a battery of plasma lipids that can differentiate Alzheimer's …

A long journey into aging, brain aging, and Alzheimer's disease following the oxidative stress tracks

P Mecocci, V Boccardi, R Cecchetti… - Journal of …, 2018‏ - journals.sagepub.com
The Editors of the Journal of Alzheimer's Disease invited Professor Patrizia Mecocci to
contribute a review article focused on the importance and implications of her research on …

The Alzheimer's disease mitochondrial cascade hypothesis: A current overview

RH Swerdlow - Journal of Alzheimer's Disease, 2023‏ - journals.sagepub.com
Viable Alzheimer's disease (AD) hypotheses must account for its age-dependence;
commonality; association with amyloid precursor protein, tau, and apolipoprotein E biology; …

Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review

A Ticinesi, C Tana, A Nouvenne, B Prati… - … interventions in aging, 2018‏ - Taylor & Francis
Cognitive frailty, defined as the coexistence of mild cognitive impairment symptoms and
physical frailty phenotype in older persons, is increasingly considered the main geriatric …

OxInflammation: from subclinical condition to pathological biomarker

G Valacchi, F Virgili, C Cervellati, A Pecorelli - Frontiers in physiology, 2018‏ - frontiersin.org
Inflammation is a complex systemic response evolved to cope with cellular injury, either due
to infectious agents or, in general, with sporadic events challenging tissue integrity and …

[HTML][HTML] Tear biomarkers in Alzheimer's and Parkinson's diseases, and multiple sclerosis: implications for diagnosis (systematic review)

A Król-Grzymała, E Sienkiewicz-Szłapka… - International Journal of …, 2022‏ - mdpi.com
Biological material is one of the most important aspects that allow for the correct diagnosis of
the disease, and tears are an interesting subject of research because of the simplicity of …