Type 2 diabetes mellitus (T2DM) is one of the major chronic diseases, whose prevalence is
increasing dramatically worldwide and can lead to a range of serious complications. Wnt …

The pancreas is derived from the foregut endoderm during embryonic development. After
gastrulation and endoderm germ layer formation complex morphogenetic events coupled …

Background Enhancers play a fundamental role in orchestrating cell state and development.
Although several methods have been developed to identify enhancers, linking them to their …

Polymorphism in TCF7L2, a component of the canonical Wnt signaling pathway, has a
strong association with β-cell dysfunction and type 2 diabetes through a mechanism that has …

Well-differentiated head and neck squamous cell carcinoma (HNSCC), accounts for
approximately 10% of all HNSCCs and, while these cases are associated with good …

Posttranscriptional modifications of histones constitute an epigenetic mechanism that is
closely linked to both gene silencing and activation events. Trimethylation of Histone3 at …

Abstract WNT9 paralogues, WNT9A and WNT9B, are secreted ligands driving both the
canonical (β-catenin dependent) and non-canonical (β-catenin independent) Wnt signaling …

Abstract The transcription factor 7-like 2 (TCF7L2) polymorphism rs7903146 is known to be
tightly associated with an elevated risk for type 2 diabetes, whereas the molecular …

Results Patient characteristics and subgroup analysis. In the discovery study, we randomly
selected 154 from a total of 1660 genotyped patients including 84 subjects with the risk …