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Therapeutic strategies for COVID-19: progress and lessons learned
G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …
The SARS-CoV-2 nucleocapsid protein: its role in the viral life cycle, structure and functions, and use as a potential target in the development of vaccines and …
W Wu, Y Cheng, H Zhou, C Sun, S Zhang - Virology journal, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) continues to take a heavy toll on personal
health, healthcare systems, and economies around the globe. Scientists are expending …
health, healthcare systems, and economies around the globe. Scientists are expending …
Ultrahigh-flux water nanopumps generated by asymmetric terahertz absorption
QL Zhang, T Zhou, C Chang, SY Gu, YJ Wang, Q Liu… - Physical Review Letters, 2024 - APS
Controlling active transport of water through membrane channels is essential for advanced
nanofluidic devices. Despite advancements in water nanopump design using techniques …
nanofluidic devices. Despite advancements in water nanopump design using techniques …
Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis
While SARS-CoV-2 continues to adapt for human infection and transmission, genetic
variation outside of the spike gene remains largely unexplored. This study investigates a …
variation outside of the spike gene remains largely unexplored. This study investigates a …
A specific phosphorylation-dependent conformational switch in SARS-CoV-2 nucleocapsid protein inhibits RNA binding
M Botova, AR Camacho-Zarco, J Tognetti… - Science …, 2024 - science.org
The nucleocapsid protein of severe acute respiratory syndrome coronavirus 2 encapsidates
the viral genome and is essential for viral function. The central disordered domain comprises …
the viral genome and is essential for viral function. The central disordered domain comprises …
Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication
Multiple coronaviruses have emerged independently in the past 20 years that cause lethal
human diseases. Although vaccine development targeting these viruses has been …
human diseases. Although vaccine development targeting these viruses has been …
Immunogenicity and reactogenicity of SARS-CoV-2 vaccines BNT162b2 and CoronaVac in healthy adolescents
We present an interim analysis of a registered clinical study (NCT04800133) to establish
immunobridging with various antibody and cellular immunity markers and to compare the …
immunobridging with various antibody and cellular immunity markers and to compare the …
Signaling mechanisms of SARS-CoV-2 Nucleocapsid protein in viral infection, cell death and inflammation
W Wang, J Chen, X Yu, HY Lan - International journal of …, 2022 - pmc.ncbi.nlm.nih.gov
COVID-19 which is caused by severe acute respiratory syndrome coronavirus (SARS-CoV-
2) has posed a worldwide pandemic and a major global public health threat. SARS-CoV-2 …
2) has posed a worldwide pandemic and a major global public health threat. SARS-CoV-2 …
[HTML][HTML] Phase separation by the SARS-CoV-2 nucleocapsid protein: Consensus and open questions
In response to the recent SARS-CoV-2 pandemic, a number of labs across the world have
reallocated their time and resources to better our understanding of the virus. For some …
reallocated their time and resources to better our understanding of the virus. For some …
Assembly of SARS-CoV-2 nucleocapsid protein with nucleic acid
The viral genome of SARS-CoV-2 is packaged by the nucleocapsid (N-) protein into
ribonucleoprotein particles (RNPs), 38±10 of which are contained in each virion. Their …
ribonucleoprotein particles (RNPs), 38±10 of which are contained in each virion. Their …