Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

The SARS-CoV-2 nucleocapsid protein: its role in the viral life cycle, structure and functions, and use as a potential target in the development of vaccines and …

W Wu, Y Cheng, H Zhou, C Sun, S Zhang - Virology journal, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) continues to take a heavy toll on personal
health, healthcare systems, and economies around the globe. Scientists are expending …

Ultrahigh-flux water nanopumps generated by asymmetric terahertz absorption

QL Zhang, T Zhou, C Chang, SY Gu, YJ Wang, Q Liu… - Physical Review Letters, 2024 - APS
Controlling active transport of water through membrane channels is essential for advanced
nanofluidic devices. Despite advancements in water nanopump design using techniques …

Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis

BA Johnson, Y Zhou, KG Lokugamage, MN Vu… - PLoS …, 2022 - journals.plos.org
While SARS-CoV-2 continues to adapt for human infection and transmission, genetic
variation outside of the spike gene remains largely unexplored. This study investigates a …

A specific phosphorylation-dependent conformational switch in SARS-CoV-2 nucleocapsid protein inhibits RNA binding

M Botova, AR Camacho-Zarco, J Tognetti… - Science …, 2024 - science.org
The nucleocapsid protein of severe acute respiratory syndrome coronavirus 2 encapsidates
the viral genome and is essential for viral function. The central disordered domain comprises …

Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication

TM Yaron, BE Heaton, TM Levy, JL Johnson… - Science …, 2022 - science.org
Multiple coronaviruses have emerged independently in the past 20 years that cause lethal
human diseases. Although vaccine development targeting these viruses has been …

Immunogenicity and reactogenicity of SARS-CoV-2 vaccines BNT162b2 and CoronaVac in healthy adolescents

JS Rosa Duque, X Wang, D Leung, SMS Cheng… - nature …, 2022 - nature.com
We present an interim analysis of a registered clinical study (NCT04800133) to establish
immunobridging with various antibody and cellular immunity markers and to compare the …

Signaling mechanisms of SARS-CoV-2 Nucleocapsid protein in viral infection, cell death and inflammation

W Wang, J Chen, X Yu, HY Lan - International journal of …, 2022 - pmc.ncbi.nlm.nih.gov
COVID-19 which is caused by severe acute respiratory syndrome coronavirus (SARS-CoV-
2) has posed a worldwide pandemic and a major global public health threat. SARS-CoV-2 …

[HTML][HTML] Phase separation by the SARS-CoV-2 nucleocapsid protein: Consensus and open questions

SM Cascarina, ED Ross - Journal of Biological Chemistry, 2022 - Elsevier
In response to the recent SARS-CoV-2 pandemic, a number of labs across the world have
reallocated their time and resources to better our understanding of the virus. For some …

Assembly of SARS-CoV-2 nucleocapsid protein with nucleic acid

H Zhao, AM Syed, MM Khalid, A Nguyen… - Nucleic Acids …, 2024 - academic.oup.com
The viral genome of SARS-CoV-2 is packaged by the nucleocapsid (N-) protein into
ribonucleoprotein particles (RNPs), 38±10 of which are contained in each virion. Their …